UniProt Accession

 LRC8A_HUMAN; Q8IWT6; Q6UXM2; Q8NCI0; Q9P2B1 

Genbank Protein ID

 AY143166; AB037858; AL672142; BC051322; AY358286; AK074723 

Genbank Nucleotide ID

 AAN18279.1; BAA92675.1; CAI10839.1; AAH51322.1; AAQ88653.1; BAC11161.1 

Protein Name

 Leucine-rich repeat-containing protein 8A 

Protein Synonyms/Alias

  

Gene Name

 LRRC8A 

Gene Synonyms/Alias

 KIAA1437; LRRC8; UNQ221/PRO247 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
501	NLRALHIKFTDIKEI	ubiquitination	[1, 2]
780	LGECPLLKRSGLVVE	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in B-cell development. Required for the pro-B cell to pre-B cell transition (By similarity). 

Sequence Annotation

 REPEAT 373 401 LRR 1.
 REPEAT 402 424 LRR 2.
 REPEAT 425 447 LRR 3.
 REPEAT 448 470 LRR 4.
 REPEAT 471 494 LRR 5.
 REPEAT 495 518 LRR 6.
 REPEAT 519 545 LRR 7.
 REPEAT 546 568 LRR 8.
 REPEAT 569 592 LRR 9.
 REPEAT 593 615 LRR 10.
 REPEAT 616 640 LRR 11.
 REPEAT 641 663 LRR 12.
 REPEAT 664 686 LRR 13.
 REPEAT 687 706 LRR 14.
 REPEAT 707 732 LRR 15.
 REPEAT 733 755 LRR 16.
 REPEAT 756 777 LRR 17.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 217 217 Phosphoserine.
 CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).
 CARBOHYD 526 526 N-linked (GlcNAc...) (Potential).
 CARBOHYD 554 554 N-linked (GlcNAc...) (Potential).
 CARBOHYD 592 592 N-linked (GlcNAc...) (Potential).
 CARBOHYD 660 660 N-linked (GlcNAc...) (Potential).
 CARBOHYD 696 696 N-linked (GlcNAc...) (Potential).
 CARBOHYD 755 755 N-linked (GlcNAc...) (Potential).  

Keyword

 Acetylation; Chromosomal rearrangement; Complete proteome; Differentiation; Direct protein sequencing; Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 810 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0002329; P:pre-B cell differentiation; ISS:UniProtKB. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR021040; LRR_protein-8_N. 

Pfam

 PF12534; DUF3733
 PF12799; LRR_4 

SMART

 SM00369; LRR_TYP 

PROSITE

 PS51450; LRR 

PRINTS