UniProt Accession

 UFD1_HUMAN; Q92890; A8MW31; Q9Y5N0 

Genbank Protein ID

 U64444; AF141201; CR456607; AK225877; AC000068; AC000087; BC001049; BC005087 

Genbank Nucleotide ID

 AAD08720.1; AAD28788.1; CAG30493.1; AAH01049.1; AAH05087.1 

Protein Name

 Ubiquitin fusion degradation protein 1 homolog 

Protein Synonyms/Alias

 UB fusion protein 1 

Gene Name

 UFD1L 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
45	SDVEKGGKIIMPPSA	ubiquitination	[1]
68	ITYPMLFKLTNKNSD	ubiquitination	[1]
175	FLDITNPKAVLENAL	ubiquitination	[1]
300	GIPNYEFKLGKITFI	ubiquitination	[1]
315	RNSRPLVKKVEEDEA	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 231 231 Phosphoserine.
 MOD_RES 245 245 Phosphoserine.
 MOD_RES 247 247 Phosphoserine.
 MOD_RES 299 299 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 307 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004843; F:ubiquitin-specific protease activity; TAS:ProtInc.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniPathway.
 GO:0001501; P:skeletal system development; TAS:ProtInc.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc. 

Interpro

 IPR004854; UFD1. 

Pfam

 PF03152; UFD1 

SMART

  

PROSITE

  

PRINTS