UniProt Accession

 SKP1_MOUSE; Q9WTX5; Q8C5H6 

Genbank Protein ID

 AF083214; AK002983; AK010628; AK012498; AK014245; AK027909; AK078330; AK088339; BC002115 

Genbank Nucleotide ID

 AAD16036.1; BAB22496.1; BAB27074.1; BAB28281.1; BAB29222.1; BAC25660.1; BAC37220.1; BAC40292.1; AAH02115.1 

Protein Name

 S-phase kinase-associated protein 1 

Protein Synonyms/Alias

 Cyclin-A/CDK2-associated protein p19; S-phase kinase-associated protein 1A; p19A; p19skp1 

Gene Name

 Skp1 

Gene Synonyms/Alias

 Skp1a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
80	EDDENKEKRTDDIPV	ubiquitination	[1]
137	KTPEEIRKTFNIKND	ubiquitination	[1]
142	IRKTFNIKNDFTEEE	ubiquitination	[1]
155	EEEAQVRKENQWCEE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. 

Sequence Annotation

 REGION 104 163 Interaction with the F-box domain of F-
 MOD_RES 131 131 Phosphothreonine (By similarity).  

Keyword

 Complete proteome; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 163 AA 

Protein Sequence

Gene Ontology

 GO:0031467; C:Cul7-RING ubiquitin ligase complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0031519; C:PcG protein complex; IEA:Compara.
 GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; IC:MGI.
 GO:0035518; P:histone H2A monoubiquitination; IEA:Compara.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB. 

Interpro

 IPR011333; BTB/POZ_fold.
 IPR016897; E3_ubiquit_lig_SCF_Skp.
 IPR001232; Skp1_comp.
 IPR016072; Skp1_comp_dimer.
 IPR016073; Skp1_comp_POZ. 

Pfam

 PF01466; Skp1
 PF03931; Skp1_POZ 

SMART

 SM00512; Skp1 

PROSITE

  

PRINTS