CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-039551
UniProt Accession
F5GWF0_HUMAN
;
F5GWF0
Genbank Protein ID
AC091609
;
AL589790
Genbank Nucleotide ID
Protein Name
Proprotein convertase subtilisin/kexin type 9
Protein Synonyms/Alias
Gene Name
PCSK9
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
43
GRDAGVA
K
GASMRSL
ubiquitination
[1]
Reference
[1] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [
PMID: 21963094
]
Functional Description
Sequence Annotation
Keyword
Complete proteome; Reference proteome.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
266 AA
Protein Sequence
MVTDFENVPE EDGTRFHRQA SKCDSHGTHL AGVVSGRDAG VAKGASMRSL RVLNCQGKGT 60
VSGTLIGLEF IRKSQLVQPV GPLVVLLPLA GGYSRVLNAA CQRLARAGVV LVTAAGNFRD 120
DACLYSPASA PEVITVGATN AQDQPVTLGT LGTNFGRCVD LFAPGEDIIG ASSDCSTCFV 180
SQSGTSQAAA HVAGIAAMML SAEPELTLAE LRQRLIHFSA KDVINEAWFP EDQRVGSCFA 240
GLYGQHTRGL HGWPQPSPAA PQMRSC 266
Gene Ontology
GO:0004252
; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508
; P:proteolysis; IEA:InterPro.
Interpro
IPR000209
; Peptidase_S8/S53_dom.
IPR015500
; Peptidase_S8_subtilisin-rel.
Pfam
PF00082
; Peptidase_S8
SMART
PROSITE
PRINTS
PR00723
; SUBTILISIN.