CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041958
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitogen-activated protein kinase kinase kinase kinase 4 
Protein Synonyms/Alias
 Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_a 
Gene Name
 MAP4K4 
Gene Synonyms/Alias
 hCG_1640439 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
46VYKGRHVKTGQLAAIubiquitination[1]
91TYYGAFIKKSPPGHDubiquitination[1]
92YYGAFIKKSPPGHDDubiquitination[1]
155HVIHRDIKGQNVLLTubiquitination[1]
261KSKKWSKKFFSFIEGubiquitination[1]
285PSTEQLLKHPFIRDQubiquitination[1]
303RQVRIQLKDHIDRTRubiquitination[1]
548PPQQERSKPSFHAPEubiquitination[1]
912EPAMTPSKEGTLIVRubiquitination[1]
932SSTLQKHKSSSSFTPubiquitination[1]
979IRQDPTRKGSVVNVNubiquitination[1]
1038LDRSGQGKVYPLINRubiquitination[1]
1092NDPEVEKKQGWTTVGubiquitination[1]
1233NTYGRITKDVVLQWGubiquitination[1]
1260QTMGWGEKAIEIRSVubiquitination[1]
1279LDGVFMHKRAQRLKFubiquitination[1]
1285HKRAQRLKFLCERNDubiquitination[1]
1293FLCERNDKVFFASVRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1320 AA 
Protein Sequence
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE 60
DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT 120
KGNTLKEDWI AYISREILRG LAHLHIHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR 240
ALFLIPRNPP PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 300
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES TLRRDFLRLQ 360
QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREAR 420
RQQEREQRRR EQEEKRRLEE LERRRKEEEE RRRAEEEKRR VEREQEYIRR QLEEEQRHLE 480
VLQQQLLQEQ AMLLECRWRE MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PHPQHSQQPP 540
PPQQERSKPS FHAPEPKAHY EPADRAREVE DRFRKTNHSS PEAQSKQTGR VLEPPVPSRS 600
ESFSNGNSES VHPALQRPAE PQVQWSHLAS LKNNVSPVSR SHSFSDPSPK FAHHHLRSQD 660
PCPPSRSEVL SQSSDSKSEA PDPTQKAWSR SDSDEVPPRV PVRTTSRSPV LSRRDSPLQG 720
SGQQNSQAGQ RNSTSSIEPR LLWERVEKLV PRPGSGSSSG SSNSGSQPGS HPGSQSGSGE 780
RFRVRSSSKS EGSPSQRLEN AVKKPEDKKE VFRPLKPAVR IDLTALAKEL RAVEDVRPPH 840
KVTDYSSSSE ESGTTDEEDD DVEQEGADES TSGPEDTRAA SSLNLSNGET ESVKTMIVHD 900
DVESEPAMTP SKEGTLIVRQ TQSASSTLQK HKSSSSFTPF IDPRLLQISP SSGTTVTSVV 960
GFSCDGMRPE AIRQDPTRKG SVVNVNPTNT RPQSDTPEIR KYKKRFNSEI LCAALWGVNL 1020
LVGTESGLML LDRSGQGKVY PLINRRRFQQ MDVLEGLNVL VTISGKKDKL RVYYLSWLRN 1080
KILHNDPEVE KKQGWTTVGD LEGCVHYKVV KYERIKFLVI ALKSSVEVYA WAPKPYHKFM 1140
AFKSFGELVH KPLLVDLTVE EGQRLKVIYG SCAGFHAVDV DSGSVYDIYL PTHIQCSIKP 1200
HAIIILPNTD GMELLVCYED EGVYVNTYGR ITKDVVLQWG EMPTSVAYIR SNQTMGWGEK 1260
AIEIRSVETG HLDGVFMHKR AQRLKFLCER NDKVFFASVR SGGSSQVYFM TLGRTSLLSW 1320 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0005083; F:small GTPase regulator activity; IEA:InterPro. 
Interpro
 IPR001180; Citron.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00780; CNH
 PF00069; Pkinase 
SMART
 SM00036; CNH
 SM00220; S_TKc 
PROSITE
 PS50219; CNH
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS