UniProt Accession

 H31_TETPY; P69149; P15511 

Genbank Protein ID

 X17141 

Genbank Nucleotide ID

 CAA35016.1 

Protein Name

 Histone H3 

Protein Synonyms/Alias

 H3S; Major histone H3; H3F 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Tetrahymena pyriformis 

NCBI Taxa ID

 5908 

Lysine Modification

Position	Peptide	Type	References
10	RTKQTARKSTGAKAP	acetylation	[1]
15	ARKSTGAKAPRKQLA	acetylation	[1]
19	TGAKAPRKQLASKAA	acetylation	[1]
24	PRKQLASKAARKSAP	acetylation	[1]

Reference

 [1] Tetrahymena histone H3. Purification and two variant sequences.
 Hayashi T, Hayashi H, Fusauchi Y, Iwai K.
 J Biochem. 1984 Jun;95(6):1741-9. [PMID: 6432775] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 5 5 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 5 5 N6,N6-dimethyllysine; alternate (By
 MOD_RES 5 5 N6-acetyllysine; alternate (By
 MOD_RES 5 5 N6-methyllysine; alternate (By
 MOD_RES 10 10 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 10 10 N6-acetyllysine; alternate.
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 15 15 N6-acetyllysine.
 MOD_RES 19 19 N6-acetyllysine.
 MOD_RES 24 24 N6-acetyllysine.
 MOD_RES 28 28 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 28 28 N6,N6-dimethyllysine; alternate (By
 MOD_RES 28 28 N6-acetyllysine; alternate (By
 MOD_RES 28 28 N6-methyllysine; alternate (By
 MOD_RES 37 37 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 37 37 N6,N6-dimethyllysine; alternate (By
 MOD_RES 37 37 N6-acetyllysine; alternate (By
 MOD_RES 37 37 N6-methyllysine; alternate (By
 MOD_RES 57 57 N6-acetyllysine; alternate (By
 MOD_RES 57 57 N6-methyllysine; alternate (By
 MOD_RES 80 80 N6-methyllysine (By similarity).  

Keyword

 Acetylation; Chromosome; Direct protein sequencing; DNA-binding; Methylation; Nucleosome core; Nucleus; Phosphoprotein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 136 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000164; Histone_H3. 

Pfam

 PF00125; Histone 

SMART

 SM00428; H3 

PROSITE

 PS00322; HISTONE_H3_1
 PS00959; HISTONE_H3_2 

PRINTS

 PR00622; HISTONEH3.