CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040138
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 GTP:AMP phosphotransferase AK3, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Ak3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
42LIQREDDKPETVIKRacetylation[1, 2, 3, 4]
48DKPETVIKRLKAYEAacetylation[1, 3, 4]
51ETVIKRLKAYEAQTEacetylation[5]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 65 AA 
Protein Sequence
XLTARWIHPA SGRVYNIEFN PPKTVGIDDL TGEPLIQRED DKPETVIKRL KAYEAQTEPV 60
LQYYQ 65 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004017; F:adenylate kinase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro. 
Interpro
 IPR000850; Adenylate_kin.
 IPR007862; Adenylate_kinase_lid-dom. 
Pfam
 PF00406; ADK
 PF05191; ADK_lid 
SMART
  
PROSITE
  
PRINTS
 PR00094; ADENYLTKNASE.