CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007476
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 1 
Protein Synonyms/Alias
 ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1 
Gene Name
 Abca1 
Gene Synonyms/Alias
 Abc1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1153SSTVSCLKKEDSVSQubiquitination[1]
1314LLSGMDGKGSYQLKGubiquitination[1]
1560DAIKQMKKLLKLTKDacetylation[2]
1824RGLIDMVKNQAMADAubiquitination[1]
1884RPRPVKAKLPPLNDEubiquitination[1]
1915QNDILEIKELTKIYRubiquitination[1]
1957AGKSTTFKMLTGDTPubiquitination[1]
2023VPEKEVGKVGEWAIRubiquitination[1]
2036IRKLGLVKYGEKYASubiquitination[1]
2040GLVKYGEKYASNYSGubiquitination[1]
2078PTTGMDPKARRFLWNubiquitination[1]
2231QSDDDHLKDLSLHKNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
 cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport (By similarity). 
Sequence Annotation
 DOMAIN 899 1131 ABC transporter 1.
 DOMAIN 1912 2144 ABC transporter 2.
 NP_BIND 933 940 ATP 1 (Potential).
 NP_BIND 1946 1953 ATP 2 (Potential).
 MOD_RES 1042 1042 Phosphoserine; by PKA (By similarity).
 MOD_RES 1141 1141 Phosphoserine.
 MOD_RES 1147 1147 Phosphoserine.
 MOD_RES 2054 2054 Phosphoserine; by PKA (By similarity).
 LIPID 3 3 S-palmitoyl cysteine (By similarity).
 LIPID 23 23 S-palmitoyl cysteine (By similarity).
 LIPID 1110 1110 S-palmitoyl cysteine (By similarity).
 LIPID 1111 1111 S-palmitoyl cysteine (By similarity).
 CARBOHYD 14 14 N-linked (GlcNAc...) (Potential).
 CARBOHYD 98 98 N-linked (GlcNAc...) (Potential).
 CARBOHYD 151 151 N-linked (GlcNAc...) (Potential).
 CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).
 CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).
 CARBOHYD 244 244 N-linked (GlcNAc...) (Potential).
 CARBOHYD 292 292 N-linked (GlcNAc...) (Potential).
 CARBOHYD 337 337 N-linked (GlcNAc...) (Potential).
 CARBOHYD 349 349 N-linked (GlcNAc...) (Potential).
 CARBOHYD 400 400 N-linked (GlcNAc...) (Potential).
 CARBOHYD 478 478 N-linked (GlcNAc...) (Potential).
 CARBOHYD 489 489 N-linked (GlcNAc...).
 CARBOHYD 521 521 N-linked (GlcNAc...) (Potential).
 CARBOHYD 820 820 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1144 1144 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1294 1294 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1453 1453 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1499 1499 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1504 1504 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1637 1637 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2044 2044 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2238 2238 N-linked (GlcNAc...) (Potential).
 DISULFID 75 309 By similarity.
 DISULFID 1463 1477 By similarity.  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Lipoprotein; Membrane; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2261 AA 
Protein Sequence
MACWPQLRLL LWKNLTFRRR QTCQLLLEVA WPLFIFLILI SVRLSYPPYE QHECHFPNKA 60
MPSAGTLPWV QGIICNANNP CFRYPTPGEA PGVVGNFNKS IVSRLFSDAQ RLLLYSQRDT 120
SIKDMHKVLR MLRQIKHPNS NLKLQDFLVD NETFSGFLQH NLSLPRSTVD SLLQANVGLQ 180
KVFLQGYQLH LASLCNGSKL EEIIQLGDAE VSALCGLPRK KLDAAERVLR YNMDILKPVV 240
TKLNSTSHLP TQHLAEATTV LLDSLGGLAQ ELFSTKSWSD MRQEVMFLTN VNSSSSSTQI 300
YQAVSRIVCG HPEGGGLKIK SLNWYEDNNY KALFGGNNTE EDVDTFYDNS TTPYCNDLMK 360
NLESSPLSRI IWKALKPLLV GKILYTPDTP ATRQVMAEVN KTFQELAVFH DLEGMWEELS 420
PQIWTFMENS QEMDLVRTLL DSRGNDQFWE QKLDGLDWTA QDIMAFLAKN PEDVQSPNGS 480
VYTWREAFNE TNQAIQTISR FMECVNLNKL EPIPTEVRLI NKSMELLDER KFWAGIVFTG 540
ITPDSVELPH HVKYKIRMDI DNVERTNKIK DGYWDPGPRA DPFEDMRYVW GGFAYLQDVV 600
EQAIIRVLTG SEKKTGVYVQ QMPYPCYVDD IFLRVMSRSM PLFMTLAWIY SVAVIIKSIV 660
YEKEARLKET MRIMGLDNGI LWFSWFVSSL IPLLVSAGLL VVILKLGNLL PYSDPSVVFV 720
FLSVFAMVTI LQCFLISTLF SRANLAAACG GIIYFTLYLP YVLCVAWQDY VGFSIKIFAS 780
LLSPVAFGFG CEYFALFEEQ GIGVQWDNLF ESPVEEDGFN LTTAVSMMLF DTFLYGVMTW 840
YIEAVFPGQY GIPRPWYFPC TKSYWFGEEI DEKSHPGSSQ KGVSEICMEE EPTHLRLGVS 900
IQNLVKVYRD GMKVAVDGLA LNFYEGQITS FLGHNGAGKT TTMSILTGLF PPTSGTAYIL 960
GKDIRSEMSS IRQNLGVCPQ HNVLFDMLTV EEHIWFYARL KGLSEKHVKA EMEQMALDVG 1020
LPPSKLKSKT SQLSGGMQRK LSVALAFVGG SKVVILDEPT AGVDPYSRRG IWELLLKYRQ 1080
GRTIILSTHH MDEADILGDR IAIISHGKLC CVGSSLFLKN QLGTGYYLTL VKKDVESSLS 1140
SCRNSSSTVS CLKKEDSVSQ SSSDAGLGSD HESDTLTIDV SAISNLIRKH VSEARLVEDI 1200
GHELTYVLPY EAAKEGAFVE LFHEIDDRLS DLGISSYGIS ETTLEEIFLK VAEESGVDAE 1260
TSDGTLPARR NRRAFGDKQS CLHPFTEDDA VDPNDSDIDP ESRETDLLSG MDGKGSYQLK 1320
GWKLTQQQFV ALLWKRLLIA RRSRKGFFAQ IVLPAVFVCI ALVFSLIVPP FGKYPSLELQ 1380
PWMYNEQYTF VSNDAPEDMG TQELLNALTK DPGFGTRCME GNPIPDTPCL AGEEDWTISP 1440
VPQSIVDLFQ NGNWTMKNPS PACQCSSDKI KKMLPVCPPG AGGLPPPQRK QKTADILQNL 1500
TGRNISDYLV KTYVQIIAKS LKNKIWVNEF RYGGFSLGVS NSQALPPSHE VNDAIKQMKK 1560
LLKLTKDSSA DRFLSSLGRF MAGLDTKNNV KVWFNNKGWH AISSFLNVIN NAILRANLQK 1620
GENPSQYGIT AFNHPLNLTK QQLSEVALMT TSVDVLVSIC VIFAMSFVPA SFVVFLIQER 1680
VSKAKHLQFI SGVKPVIYWL SNFVWDMCNY VVPATLVIII FICFQQKSYV SSTNLPVLAL 1740
LLLLYGWSIT PLMYPASFVF KIPSTAYVVL TSVNLFIGIN GSVATFVLEL FTNNKLNDIN 1800
DILKSVFLIF PHFCLGRGLI DMVKNQAMAD ALERFGENRF VSPLSWDLVG RNLFAMAVEG 1860
VVFFLITVLI QYRFFIRPRP VKAKLPPLND EDEDVRRERQ RILDGGGQND ILEIKELTKI 1920
YRRKRKPAVD RICIGIPPGE CFGLLGVNGA GKSTTFKMLT GDTPVTRGDA FLNKNSILSN 1980
IHEVHQNMGY CPQFDAITEL LTGREHVEFF ALLRGVPEKE VGKVGEWAIR KLGLVKYGEK 2040
YASNYSGGNK RKLSTAMALI GGPPVVFLDE PTTGMDPKAR RFLWNCALSI VKEGRSVVLT 2100
SHSMEECEAL CTRMAIMVNG RFRCLGSVQH LKNRFGDGYT IVVRIAGSNP DLKPVQEFFG 2160
LAFPGSVLKE KHRNMLQYQL PSSLSSLARI FSILSQSKKR LHIEDYSVSQ TTLDQVFVNF 2220
AKDQSDDDHL KDLSLHKNQT VVDVAVLTSF LQDEKVKESY V 2261 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0045335; C:phagocytic vesicle; IEA:Compara.
 GO:0008509; F:anion transmembrane transporter activity; IDA:BHF-UCL.
 GO:0034188; F:apolipoprotein A-I receptor activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0017127; F:cholesterol transporter activity; IDA:MGI.
 GO:0005548; F:phospholipid transporter activity; IDA:MGI.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0071222; P:cellular response to lipopolysaccharide; IDA:UniProtKB.
 GO:0071300; P:cellular response to retinoic acid; IDA:UniProtKB.
 GO:0033344; P:cholesterol efflux; IDA:MGI.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IDA:MGI.
 GO:0016197; P:endosomal transport; IEA:Compara.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0034380; P:high-density lipoprotein particle assembly; IEA:Compara.
 GO:0050702; P:interleukin-1 beta secretion; IEA:Compara.
 GO:0032367; P:intracellular cholesterol transport; IEA:Compara.
 GO:0007040; P:lysosome organization; IEA:Compara.
 GO:0002790; P:peptide secretion; IMP:MGI.
 GO:0006911; P:phagocytosis, engulfment; IMP:MGI.
 GO:0033700; P:phospholipid efflux; IDA:MGI.
 GO:0055091; P:phospholipid homeostasis; IEA:Compara.
 GO:0045332; P:phospholipid translocation; IMP:MGI.
 GO:0060155; P:platelet dense granule organization; IEA:Compara.
 GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Compara.
 GO:0010875; P:positive regulation of cholesterol efflux; IMP:BHF-UCL.
 GO:0006497; P:protein lipidation; IMP:MGI.
 GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Compara.
 GO:0034616; P:response to laminar fluid shear stress; IEA:Compara.
 GO:0055098; P:response to low-density lipoprotein particle stimulus; IEA:Compara.
 GO:0043691; P:reverse cholesterol transport; IMP:BHF-UCL. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS