CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008592
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial distribution and morphology protein 34 
Protein Synonyms/Alias
 Mitochondrial outer membrane protein MMM2 
Gene Name
 MDM34 
Gene Synonyms/Alias
 MMM2; YGL219C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
293SQSFPQPKSSTVSSKubiquitination[1]
300KSSTVSSKQLVKPFYubiquitination[1]
304VSSKQLVKPFYCSHNubiquitination[1]
330YDLATITKIQSRLFDubiquitination[1]
410TTVSIRDKYVIPEKIubiquitination[1]
416DKYVIPEKISLNLDSubiquitination[1]
430SKKDTSKKKPFYFIGubiquitination[1, 2]
431KKDTSKKKPFYFIGLubiquitination[1]
448QEPSNNWKWGMEDSPubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. 
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Transmembrane; Transmembrane beta strand; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 459 AA 
Protein Sequence
MSFRFNEAVF GDNSFNERIR EKLSTALNSP SKKKLDILKS GIKVQKVDFP TIPQLEILDL 60
DIITQPKSLA KGICKISCKD AMLRIQTVIE SNLLLINEQD TPSFTMPQLI NNGSFTIPIT 120
MTFSSIELEA ITNIFVKNPG IGISFNDVDL DFKFDCSVKI LQSTIERRLK ESMHVVFKDV 180
LPSLIFNTSQ NWFTNRGEST STIPGKREHH HQQTTMSRNV ILDGSDFQEL SPINMLRLSS 240
IVSSRSTLSL HSTVMNSLSA IPGCLERQNL YRFISRMPSL NNYYSSQSFP QPKSSTVSSK 300
QLVKPFYCSH NLLPKTVLDS SQYDLATITK IQSRLFDRSN SNDDNAKPRR RKIKCKKTRT 360
PSNLQSQGEQ AVDDSTAIET VTSTPVQTPI PELEEQSPPY LKTTVSIRDK YVIPEKISLN 420
LDSKKDTSKK KPFYFIGLNS QEPSNNWKWG MEDSPPPYH 459 
Gene Ontology
 GO:0032865; C:ERMES complex; IPI:SGD.
 GO:0031307; C:integral to mitochondrial outer membrane; IEA:HAMAP.
 GO:0000002; P:mitochondrial genome maintenance; IEA:HAMAP.
 GO:0007005; P:mitochondrion organization; IMP:SGD.
 GO:0015914; P:phospholipid transport; IGI:SGD. 
Interpro
 IPR027536; Mdm34. 
Pfam
  
SMART
  
PROSITE
  
PRINTS