UniProt Accession

 DD19A_HUMAN; Q9NUU7; B2RPL0; Q53FM0 

Genbank Protein ID

 AK001988; AK223262; AL832970; CH471241; BC005162; BC006544; BC137496; BC137497 

Genbank Nucleotide ID

 BAA92022.1; BAD96982.1; CAH10622.1; EAW51826.1; AAH05162.1; AAH06544.1; AAI37497.1; AAI37498.1 

Protein Name

 ATP-dependent RNA helicase DDX19A 

Protein Synonyms/Alias

 DDX19-like protein; DEAD box protein 19A 

Gene Name

 DDX19A 

Gene Synonyms/Alias

 DDX19L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	AAQSLLNKLIRSNLV	ubiquitination	[1]
91	NSPLYSVKSFEELRL	ubiquitination	[1]
228	LDWCSKLKFIDPKKI	acetylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity). 

Sequence Annotation

 DOMAIN 124 294 Helicase ATP-binding.
 DOMAIN 305 473 Helicase C-terminal.
 NP_BIND 137 144 ATP (By similarity).
 REGION 2 299 N-terminal lobe (By similarity).
 REGION 54 67 N-terminal helix (By similarity).
 REGION 300 478 C-terminal lobe (By similarity).
 MOTIF 91 119 Q motif.
 MOTIF 241 244 DEAD box.
 BINDING 118 118 ATP (By similarity).
 BINDING 428 428 ATP (By similarity).
 BINDING 431 431 ATP (By similarity).
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; Membrane; mRNA transport; Nuclear pore complex; Nucleotide-binding; Nucleus; Protein transport; Reference proteome; RNA-binding; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 478 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0010043; P:response to zinc ion; IEA:Compara. 

Interpro

 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR014014; RNA_helicase_DEAD_Q_motif. 

Pfam

 PF00270; DEAD
 PF00271; Helicase_C 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 

PRINTS