CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043938
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mediator of RNA polymerase II transcription subunit 14 
Protein Synonyms/Alias
  
Gene Name
 MED14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
142EPGVIMFKTDALKCRubiquitination[1]
155CRVALSPKTNQTLQLubiquitination[2, 3, 4]
194RVAGPPFKANTLIAFubiquitination[5]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 331 AA 
Protein Sequence
PSGRAGNWPG SPQVSGPSPA ARMPGMSPAN PSLHSPVPDA SHSPRAGTSS QTMPTNMPPP 60
RKLPQRSWAA SIPTILTHSA LNILLLPSPT PGLVPGLAGS YLCSPLERFL GSVIMRRHLQ 120
RIIQQETLQL INSNEPGVIM FKTDALKCRV ALSPKTNQTL QLKVTPENAG QWKPDELQVL 180
EKFFETRVAG PPFKANTLIA FTKLLGAPTH ILRDCVHIMK LELFPDQATQ LKWNVQFCLT 240
IPPSAPPIAP PGTPAVVLKS KMLFFLQLTQ KTSVPPQEPV SIIVPIIYDM ASGTTQQADI 300
PRQQNSSVAA PMMVSNILKR FAEMNPPRQG T 331 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS