UniProt Accession

 UCRI_HUMAN; P47985; A8K519; Q6NVX5; Q9UPH2 

Genbank Protein ID

 L32977; L32917; AK291134; AC007786; BC000649; BC010035; BC067832 

Genbank Nucleotide ID

 AAC41754.1; AAC41754.1; BAF83823.1; AAD38242.1; AAH00649.1; AAH10035.1; AAH67832.1 

Protein Name

 Cytochrome b-c1 complex subunit Rieske, mitochondrial 

Protein Synonyms/Alias

 Complex III subunit 5; Cytochrome b-c1 complex subunit 5; Rieske iron-sulfur protein; RISP; Ubiquinol-cytochrome c reductase iron-sulfur subunit; Cytochrome b-c1 complex subunit 11; Complex III subunit IX; Ubiquinol-cytochrome c reductase 8 kDa protein 

Gene Name

 UQCRFS1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
163	LSDIPEGKNMAFKWR	ubiquitination	[1, 2]
168	EGKNMAFKWRGKPLF	ubiquitination	[1, 2]
182	FVRHRTQKEIEQEAA	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. 

Sequence Annotation

 DOMAIN 187 272 Rieske.
 METAL 217 217 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 219 219 Iron-sulfur (2Fe-2S); via pros nitrogen
 METAL 236 236 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 239 239 Iron-sulfur (2Fe-2S); via pros nitrogen
 DISULFID 222 238 By similarity.  

Keyword

 2Fe-2S; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Polymorphism; Reference proteome; Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005750; C:mitochondrial respiratory chain complex III; NAS:UniProtKB.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008121; F:ubiquinol-cytochrome-c reductase activity; NAS:UniProtKB.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR011070; Globular_prot_asu/bsu.
 IPR017941; Rieske_2Fe-2S.
 IPR014349; Rieske_Fe-S_prot.
 IPR005805; Rieske_Fe-S_prot_C.
 IPR015248; Ubiqinol_cyt_c_Rdtase_N.
 IPR006317; Ubiquinol_cyt_c_Rdtase_Fe-S-su.
 IPR004192; Ubiquinol_cyt_Rdtase_TM. 

Pfam

 PF00355; Rieske
 PF09165; Ubiq-Cytc-red_N
 PF02921; UCR_TM 

SMART

  

PROSITE

 PS51296; RIESKE 

PRINTS

 PR00162; RIESKE.