CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044414
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 THUMP domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 THUMPD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
264AFLEDMKKYAETFLEubiquitination[1]
275TFLEPWFKAPNKGTFubiquitination[1]
340VCCLSVVKDYMLFRKubiquitination[1, 2, 3]
358QEVVKSPKDPSQLNSubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 439 AA 
Protein Sequence
MAAMLPLLDS GCSREAGQEA GLGRVSLHPF HDCRPALGPG AARNEASRPA RGGRRSYPTS 60
PVRAGDRRGR QQQRRNVSLS SQFAHTMAAP AQQTTQPGGG KRKGKAQYVL AKRARRCDAG 120
GPRQLEPGLQ GILITCNMNE RKCVEEAYSL LNEYGDDMYG PEKFTDKDQQ PSGSEGEDDD 180
AEAALKKEVG DIKASTEMRL RRFQSVESGA NNVVFIRTLG IEPEKLVHHI LQDMYKTKKK 240
KTRVILRMLP ISGTCKAFLE DMKKYAETFL EPWFKAPNKG TFQIVYKSRN NSHVNREEVI 300
RELAGIVCTL NSENKVDLTN PQYTVVVEII KAVCCLSVVK DYMLFRKYNL QEVVKSPKDP 360
SQLNSKQGNG KEAKLESADK SDQNNTAEGK NNQQVPENTE ELGQTKPTSN PQVVNEGGAK 420
PELASQATEG SKSNENDFS 439 
Gene Ontology
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR004114; THUMP. 
Pfam
 PF02926; THUMP 
SMART
 SM00981; THUMP 
PROSITE
 PS51165; THUMP 
PRINTS