CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017157
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 7 
Protein Synonyms/Alias
 ABCA-SSN; Autoantigen SS-N; Macrophage ABC transporter 
Gene Name
 ABCA7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
794QDVGLVSKQSVQTRHubiquitination[1]
1041LDVTLRLKMPPQETAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. 
Sequence Annotation
 DOMAIN 807 1038 ABC transporter 1.
 DOMAIN 1793 2025 ABC transporter 2.
 NP_BIND 841 848 ATP 1 (Potential).
 NP_BIND 1827 1834 ATP 2 (Potential).
 CARBOHYD 312 312 N-linked (GlcNAc...) (Potential).
 DISULFID 75 225 By similarity.
 DISULFID 1345 1359 By similarity.  
Keyword
 Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Disulfide bond; Endosome; Glycoprotein; Golgi apparatus; Membrane; Nucleotide-binding; Phagocytosis; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2146 AA 
Protein Sequence
MVCLGTGQSA GPLVSVQNHC PPCGLSPQES LGLALGQAQE PLHSLLEAAE DLAQELLALR 60
SLVELRALLQ RPRGTSGPLE LLSEALCSVR GPSSTVGPSL NWYEASDLME LVGQEPESAL 120
PDSSLSPACS ELIGALDSHP LSRLLWRRLK PLILGKLLFA PDTPFTRKLM AQVNRTFEEL 180
TLLRDVREVW EMLGPRIFTF MNDSSNVAML QRLLQMQDEG RRQPRPGGRD HMEALRSFLD 240
PGSGGYSWQD AHADVGHLVG TLGRVTECLS LDKLEAAPSE AALVSRALQL LAEHRFWAGV 300
VFLGPEDSSD PTEHPTPDLG PGHVRIKIRM DIDVVTRTNK IRDRFWDPGP AADPLTDLRY 360
VWGGFVYLQD LVERAAVRVL SGANPRAGLY LQQMPYPCYV DDVFLRVLSR SLPLFLTLAW 420
IYSVTLTVKA VVREKETRLR DTMRAMGLSR AVLWLGWFLS CLGPFLLSAA LLVLVLKLGD 480
ILPYSHPGVV FLFLAAFAVA TVTQSFLLSA FFSRANLAAA CGGLAYFSLY LPYVLCVAWR 540
DRLPAGGRVA ASLLSPVAFG FGCESLALLE EQGEGAQWHN VGTRPTADVF SLAQVSGLLL 600
LDAALYGLAT WYLEAVCPGQ YGIPEPWNFP FRRSYWCGPR PPKSPAPCPT PLDPKVLVEE 660
APPGLSPGVS VRSLEKRFPG SPQPALRGLS LDFYQGHITA FLGHNGAGKT TTLSILSGLF 720
PPSGGSAFIL GHDVRSSMAA IRPHLGVCPQ YNVLFDMLTV DEHVWFYGRL KGLSAAVVGP 780
EQDRLLQDVG LVSKQSVQTR HLSGGMQRKL SVAIAFVGGS QVVILDEPTA GVDPASRRGI 840
WELLLKYREG RTLILSTHHL DEAELLGDRV AVVAGGRLCC CGSPLFLRRH LGSGYYLTLV 900
KARLPLTTNE KADTDMEGSV DTRQEKKNGS QGSRVGTPQL LALVQHWVPG ARLVEELPHE 960
LVLVLPYTGA HDGSFATLFR ELDTRLAELR LTGYGISDTS LEEIFLKVVE ECAADTDMED 1020
GSCGQHLCTG IAGLDVTLRL KMPPQETALE NGEPAGSAPE TDQGSGPDAV GRVQGWALTR 1080
QQLQALLLKR FLLARRSRRG LFAQIVLPAL FVGLALVFSL IVPPFGHYPA LRLSPTMYGA 1140
QVSFFSEDAP GDPGRARLLE ALLQEAGLEE PPVQHSSHRF SAPEVPAEVA KVLASGNWTP 1200
ESPSPACQCS RPGARRLLPD CPAAAGGPPP PQAVTGSGEV VQNLTGRNLS DFLVKTYPRL 1260
VRQGLKTKKW VNEVRYGGFS LGGRDPGLPS GQELGRSVEE LWALLSPLPG GALDRVLKNL 1320
TAWAHSLDAQ DSLKIWFNNK GWHSMVAFVN RASNAILRAH LPPGPARHAH SITTLNHPLN 1380
LTKEQLSEGA LMASSVDVLV SICVVFAMSF VPASFTLVLI EERVTRAKHL QLMGGLSPTL 1440
YWLGNFLWDM CNYLVPACIV VLIFLAFQQR AYVAPANLPA LLLLLLLYGW SITPLMYPAS 1500
FFFSVPSTAY VVLTCINLFI GINGSMATFV LELFSDQKLQ EVSRILKQVF LIFPHFCLGR 1560
GLIDMVRNQA MADAFERLGD RQFQSPLRWE VVGKNLLAMV IQGPLFLLFT LLLQHRSQLL 1620
PQPRVRSLPL LGEEDEDVAR ERERVVQGAT QGDVLVLRNL TKVYRGQRMP AVDRLCLGIP 1680
PGECFGLLGV NGAGKTSTFR MVTGDTLASR GEAVLAGHSV AREPSAAHLS MGYCPQSDAI 1740
FELLTGREHL ELLARLRGVP EAQVAQTAGS GLARLGLSWY ADRPAGTYSG GNKRKLATAL 1800
ALVGDPAVVF LDEPTTGMDP SARRFLWNSL LAVVREGRSV MLTSHSMEEC EALCSRLAIM 1860
VNGRFRCLGS PQHLKGRFAA GHTLTLRVPA ARSQPAAAFV AAEFPGAELR EAHGGRLRFQ 1920
LPPGGRCALA RVFGELAVHG AEHGVEDFSV SQTMLEEVFL YFSKDQGKDE DTEEQKEAGV 1980
GVDPAPGLQH PKRVSQFLDD PSTAETVL 2008 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0043190; C:ATP-binding cassette (ABC) transporter complex; TAS:ProtInc.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005524; F:ATP binding; TAS:ProtInc.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0005548; F:phospholipid transporter activity; IEA:Compara.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS