UniProt Accession

 BLNK_RAT; Q4KM52 

Genbank Protein ID

 BC098790 

Genbank Nucleotide ID

 AAH98790.1 

Protein Name

 B-cell linker protein 

Protein Synonyms/Alias

 Cytoplasmic adapter protein 

Gene Name

 Blnk 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
14	ITVPASQKLRQLQKM	acetylation	[1]
302	PVFPPTQKPVLQKPV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis (By similarity). 

Sequence Annotation

 DOMAIN 347 454 SH2.
 MOD_RES 72 72 Phosphotyrosine; by SYK (By similarity).
 MOD_RES 84 84 Phosphotyrosine; by SYK (By similarity).
 MOD_RES 96 96 Phosphotyrosine; by SYK (By similarity).
 MOD_RES 178 178 Phosphotyrosine; by SYK (By similarity).
 MOD_RES 189 189 Phosphotyrosine; by SYK (By similarity).  

Keyword

 B-cell activation; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; SH2 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 457 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:Compara. 

Interpro

 IPR000980; SH2. 

Pfam

 PF00017; SH2 

SMART

 SM00252; SH2 

PROSITE

 PS50001; SH2 

PRINTS