CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021441
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acyl-CoA synthetase short-chain family member 3, mitochondrial 
Protein Synonyms/Alias
 Acyl-CoA synthetase short-chain family member 3 
Gene Name
 ACSS3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
524WKNQEAFKHLYFEKFacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Activates acetate so that it can be used for lipid synthesis or for energy generation (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Ligase; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 686 AA 
Protein Sequence
MKPSWLQCRK VTSAGGLGGP LPGSSPARGA GAALRALVVP GPRGGLGGRG CRALSSGSGS 60
EYKTHFAASV TDPERFWGKA AEQISWYKPW TKTLENKHSP STRWFVEGML NICYNAVDRH 120
IENGKGDKIA IIYDSPVTNT KATFTYKEVL EQVSKLAGVL VKHGIKKGDT VVIYMPMIPQ 180
AMYTMLACAR IGAIHSLIFG GFASKELSSR IDHVKPKVVV TASFGIEPGR RVEYVPLVEE 240
ALKIGQHKPD KILIYNRPNM EAVPLAPGRD LDWDEEMAKA QSHDCVPVLS EHPLYILYTS 300
GTTGLPKGVI RPTGGYAVML HWSMSSIYGL QPGEVWWAAS DLGWVVGHSY ICYGPLLHGN 360
TTVLYEGKPV GTPDAGAYFR VLAEHGVAAL FTAPTAIRAI RQQDPGAALG KQYSLTRFKT 420
LFVAGERCDV ETLEWSKNVF RVPVLDHWWQ TETGSPITAS CVGLGNSKTP PPGQAGKSVP 480
GYNVMILDDN MQKLKARCLG NIVVKLPLPP GAFSGLWKNQ EAFKHLYFEK FPGYYDTMDA 540
GYMDEEGYLY VMSRVDDVIN VAGHRISAGA IEESILSHGT VADCAVVGKE DPLKGHVPLA 600
LCVLRKDINA TEEQVLEEIV KHVRQNIGPV AAFRNAVFVK QLPKTRSGKI PRSALSAIVN 660
GKPYKITSTI EDPSIFGHVE EMLKQA 686 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0003987; F:acetate-CoA ligase activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR024597; Acyl-CoA_synth_DUF3448.
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR025110; DUF4009. 
Pfam
 PF00501; AMP-binding
 PF11930; DUF3448
 PF13193; DUF4009 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS