CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019863
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial 
Protein Synonyms/Alias
 Glu-AdT subunit B; Cytochrome c oxidase assembly factor PET112 homolog 
Gene Name
 Pet112 
Gene Synonyms/Alias
 Pet112l 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
529RNPKAINKLIGLVRKacetylation[1, 2]
529RNPKAINKLIGLVRKsuccinylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Ligase; Mitochondrion; Nucleotide-binding; Protein biosynthesis; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MAAPMLRLGF PGRRWALTWL DGGSRHRSGS QTGPTSNWAR RQSSVAQPSL HTAQKPRKGE 60
HKWAAVVGLE IHAQISSNSK LFSGAQVCFA APPNSLVSYF DASLPGTLPV LNRRCVEAAV 120
MTGLALNCHI NKKSLFDRKH YFYSDLPAGY QITQQRLPIA ANGHLTYCIY LGKKPSQVTT 180
KTVRIKQIQL EQDSGKSLHD DLRSQTLIDL NRAGIGLLEV VLEPDLCCGE EAALAVRELQ 240
LILQALGTSQ ANMAEGQLRV DANISVHHPG EPLGVRTEVK NLNSLRFLAK AIDYEIQRQI 300
TELENGGEIL NETRSFDYKL GCTMPMRDKE GKQDYRFMPE PNLPPLVLYD DTSLPRGADS 360
QQVINIDQLR DMLPELPSAT RERLVQQYGM LPEHSFALLN EVGLLEFFQN VIKETRTEPK 420
KVTNWVLNTF LCYLKQQNLA VSESPVTPSA LAELLNLLDR KAISSSAAKQ VFEELWKGEG 480
KTAAQIVSEQ QLELMQDQEA LEKLCQTTID GHPQVVMDVK KRNPKAINKL IGLVRKASHS 540
RADPALIKKI LERKLSL 557 
Gene Ontology
 GO:0030956; C:glutamyl-tRNA(Gln) amidotransferase complex; IEA:HAMAP.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0050567; F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity; IEA:HAMAP.
 GO:0070681; P:glutaminyl-tRNAGln biosynthesis via transamidation; IEA:HAMAP.
 GO:0032543; P:mitochondrial translation; IEA:HAMAP. 
Interpro
 IPR004413; Apn/Gln-ADT_bsu.
 IPR017959; Asn/Gln-tRNA_amidoTrfase_suB/E.
 IPR006075; Asn/Gln-tRNA_Trfase_suB/E_cat.
 IPR018027; Asn/Gln_amidotransferase.
 IPR003789; Asn/Gln_tRNA_amidoTrfrase-rel.
 IPR017958; Gln-tRNA_amidoTrfase_suB_CS. 
Pfam
 PF02934; GatB_N
 PF02637; GatB_Yqey 
SMART
 SM00845; GatB_Yqey 
PROSITE
 PS01234; GATB 
PRINTS