UniProt Accession

 ACMSD_HUMAN; Q8TDX5; Q3B7X3; Q53SR5; Q96KY2 

Genbank Protein ID

 AB071418; AC016725; CH471058; CH471058; CH471058; BC016018; BC107420 

Genbank Nucleotide ID

 BAB86938.1; AAY14997.1; EAX11650.1; EAX11651.1; EAX11652.1; AAH16018.1; AAI07421.1 

Protein Name

 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase 

Protein Synonyms/Alias

 Picolinate carboxylase 

Gene Name

 ACMSD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
256	QDNPMNPKKYLGSFY	methylation	[1]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. 

Sequence Annotation

 METAL 6 6 Zinc.
 METAL 8 8 Zinc.
 METAL 174 174 Zinc.
 METAL 291 291 Zinc.
 BINDING 47 47 Substrate (Probable).
 MOD_RES 116 116 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Decarboxylase; Lyase; Metal-binding; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 336 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0001760; F:aminocarboxymuconate-semialdehyde decarboxylase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046874; P:quinolinate metabolic process; IDA:UniProtKB.
 GO:0006569; P:tryptophan catabolic process; TAS:Reactome. 

Interpro

 IPR006992; Amidohydro_2. 

Pfam

 PF04909; Amidohydro_2 

SMART

  

PROSITE

  

PRINTS