CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004641
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Insulin-like growth factor-binding protein 2 
Protein Synonyms/Alias
 IBP-2; IGF-binding protein 2; IGFBP-2 
Gene Name
 IGFBP2 
Gene Synonyms/Alias
 BP2; IBP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
292CVNPNTGKLIQGAPTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. 
Sequence Annotation
 DOMAIN 38 134 IGFBP N-terminal.
 DOMAIN 224 306 Thyroglobulin type-1.
 MOTIF 301 303 Cell attachment site.
 DISULFID 227 261
 DISULFID 272 283
 DISULFID 285 306  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Growth factor binding; Growth regulation; Polymorphism; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 325 AA 
Protein Sequence
MLPRVGCPAL PLPPPPLLPL LLLLLGASGG GGGARAEVLF RCPPCTPERL AACGPPPVAP 60
PAAVAAVAGG ARMPCAELVR EPGCGCCSVC ARLEGEACGV YTPRCGQGLR CYPHPGSELP 120
LQALVMGEGT CEKRRDAEYG ASPEQVADNG DDHSEGGLVE NHVDSTMNML GGGGSAGRKP 180
LKSGMKELAV FREKVTEQHR QMGKGGKHHL GLEEPKKLRP PPARTPCQQE LDQVLERIST 240
MRLPDERGPL EHLYSLHIPN CDKHGLYNLK QCKMSLNGQR GECWCVNPNT GKLIQGAPTI 300
RGDPECHLFY NEQQEARGVH TQRMQ 325 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0031994; F:insulin-like growth factor I binding; IDA:UniProtKB.
 GO:0031995; F:insulin-like growth factor II binding; ISS:UniProtKB.
 GO:0007568; P:aging; IEA:Compara.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0032870; P:cellular response to hormone stimulus; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0042104; P:positive regulation of activated T cell proliferation; IDA:BHF-UCL.
 GO:0001558; P:regulation of cell growth; IEA:InterPro.
 GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0010226; P:response to lithium ion; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0006950; P:response to stress; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:Compara. 
Interpro
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR012210; IGFBP-2.
 IPR000867; IGFBP-like.
 IPR009168; IGFBP1-6.
 IPR022321; IGFBP_1-6_chordata.
 IPR017891; Insulin_GF-bd_Cys-rich_CS.
 IPR000716; Thyroglobulin_1. 
Pfam
 PF00219; IGFBP
 PF00086; Thyroglobulin_1 
SMART
 SM00121; IB
 SM00211; TY 
PROSITE
 PS00222; IGFBP_N_1
 PS51323; IGFBP_N_2
 PS00484; THYROGLOBULIN_1_1
 PS51162; THYROGLOBULIN_1_2 
PRINTS
 PR01976; IGFBPFAMILY.
 PR01978; IGFBPFAMILY2.