CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024205
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Extended synaptotagmin-2 
Protein Synonyms/Alias
 E-Syt2; Chr2Syt 
Gene Name
 ESYT2 
Gene Synonyms/Alias
 FAM62B; KIAA1228 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
200ERAEWLNKTVKHMWPubiquitination[1]
239LSTFSFTKVDVGQQPubiquitination[2]
384QLRFPVPKGVLRIHFubiquitination[1]
400EAQDLQGKDTYLKGLubiquitination[1]
405QGKDTYLKGLVKGKSubiquitination[1, 2]
411LKGLVKGKSDPYGIIubiquitination[1, 3]
431IFQSRVIKENLSPKWubiquitination[1]
498LDEVPKGKLHLRLEWubiquitination[1]
562FNPDVLKKTAVQRALubiquitination[1]
599QESKIRYKTNEPVWEubiquitination[1]
668SGPNSTIKMKIALRVubiquitination[1]
670PNSTIKMKIALRVLHubiquitination[1]
680LRVLHLEKRERPPDHubiquitination[1]
896RTLDVAVKNSGGFLSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 May play a role as calcium-regulated intrinsic membrane protein. 
Sequence Annotation
 DOMAIN 372 473 C2 1.
 DOMAIN 523 617 C2 2.
 DOMAIN 788 892 C2 3.
 MOD_RES 691 691 Phosphoserine.
 MOD_RES 738 738 Phosphoserine (By similarity).
 MOD_RES 739 739 Phosphoserine.
 MOD_RES 743 743 Phosphoserine.
 MOD_RES 748 748 Phosphoserine.
 MOD_RES 755 755 Phosphoserine.
 MOD_RES 758 758 Phosphoserine.
 MOD_RES 761 761 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 921 AA 
Protein Sequence
MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS HAPGSRLGAR 60
RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN PGGVLSVELP GLLAQLARSF 120
ALLLPVYALG YLGLSFSWVL LALALLAWCR RSRGLKALRL CRALALLEDE ERVVRLGVRA 180
CDLPAWVHFP DTERAEWLNK TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV 240
DVGQQPLRIN GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM 300
RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI ILDIISNYLV 360
LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK DTYLKGLVKG KSDPYGIIRV 420
GNQIFQSRVI KENLSPKWNE VYEALVYEHP GQELEIELFD EDPDKDDFLG SLMIDLIEVE 480
KERLLDEWFT LDEVPKGKLH LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL 540
YLDSARNLPS NPLEFNPDVL KKTAVQRALK SGKKISSNPN PVVQMSVGHK AQESKIRYKT 600
NEPVWEENFT FFIHNPKRQD LEVEVRDEQH QCSLGNLKVP LSQLLTSEDM TVSQRFQLSN 660
SGPNSTIKMK IALRVLHLEK RERPPDHQHS AQVKRPSVSK EGRKTSIKSH MSGSPGPGGS 720
NTAPSTPVIG GSDKPGMEEK AQPPEAGPQG LHDLGRSSSS LLASPGHISV KEPTPSIASD 780
ISLPIATQEL RQRLRQLENG TTLGQSPLGQ IQLTIRHSSQ RNKLIVVVHA CRNLIAFSED 840
GSDPYVRMYL LPDKRRSGRR KTHVSKKTLN PVFDQSFDFS VSLPEVQRRT LDVAVKNSGG 900
FLSKDKGLLG KVLVALASEE LAKGWTQWYD LTEDGTRPQA MT 942 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting. 
Pfam
 PF00168; C2 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS