CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023551
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transgelin-2 
Protein Synonyms/Alias
 SM22-beta 
Gene Name
 Tagln2 
Gene Synonyms/Alias
 Kiaa0120 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
17LSREVQQKIEKQYDAacetylation[1, 2]
20EVQQKIEKQYDADLEacetylation[1, 3]
57ENFQKWLKDGTVLCKacetylation[1]
64KDGTVLCKLINSLYPacetylation[1]
78PEGQAPVKKIQASSMacetylation[1, 2, 4]
78PEGQAPVKKIQASSMsuccinylation[2]
79EGQAPVKKIQASSMAacetylation[1]
88QASSMAFKQMEQISQacetylation[1]
120TVDLWEGKNMACVQRacetylation[1]
153GDPNWFPKKSKENPRacetylation[1, 4]
171DNQLQEGKNVIGLQMacetylation[1]
171DNQLQEGKNVIGLQMubiquitination[5]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 DOMAIN 24 136 CH.
 REPEAT 174 199 Calponin-like.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 17 17 N6-acetyllysine (By similarity).
 MOD_RES 20 20 N6-acetyllysine (By similarity).
 MOD_RES 163 163 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 199 AA 
Protein Sequence
MANRGPSYGL SREVQQKIEK QYDADLEQIL IQWITTQCRE DVGQPQPGRE NFQKWLKDGT 60
VLCKLINSLY PEGQAPVKKI QASSMAFKQM EQISQFLQAA ERYGINTTDI FQTVDLWEGK 120
NMACVQRTLM NLGGLAVARD DGLFSGDPNW FPKKSKENPR NFSDNQLQEG KNVIGLQMGT 180
NRGASQAGMT GYGMPRQIL 199 
Gene Ontology
 GO:0007517; P:muscle organ development; IEA:InterPro. 
Interpro
 IPR000557; Calponin_repeat.
 IPR001715; CH-domain.
 IPR003096; SM22_calponin.
 IPR001061; TAGLN. 
Pfam
 PF00402; Calponin
 PF00307; CH 
SMART
 SM00033; CH 
PROSITE
 PS01052; CALPONIN_1
 PS51122; CALPONIN_2
 PS50021; CH 
PRINTS
 PR00888; SM22CALPONIN.