CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041096
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ephrin type-A receptor 6 
Protein Synonyms/Alias
  
Gene Name
 Epha6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
931AYTTTGGKIPIRWTAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1130 AA 
Protein Sequence
MQFPSPPAAR SSPAAQAASS PQAAAPAPGQ PGPSCPAHRA SRGGRPGTSP ADRVEEEEEE 60
EEEEESLVQD PHATRNTWLR CCHFFLRRRR EPTRAMGGCE VREFLLQFGF FLPLLTAWTG 120
DCSHVSNQVV LLDTTTVMGE LGWKTYPLNG WDAITEMDEH NRPIHTYQVC NVMEPNQNNW 180
LRTNWISRDA AQKIYVEMKF TLRDCNSIPW VLGTCKETFN LYYIESDESH GTKFKPSQYI 240
KIDTIAADES FTQMDLGDRI LKLNTEIREV GPIERKGFYL AFQDIGACIA LVSVRVFYKK 300
CPFTVRNLAM FPDTIPRVDS SSLVEVRGSC VKSAEERDTP KLYCGADGDW LVPLGRCICS 360
TGYEEIEGSC HACRPGFYKA FAGNTKCSKC PPHSSTYVEA TSVCHCEKGY FRAEKDPPSM 420
ACTRPPSAPR NVAFNINETA LILEWSPPSD TGGRKDLTYS VICKKCGLDT TQCEDCGGGL 480
RFIPRHTGLI NNSVVVLDFV SHVNYTFEIE AMNGVSELSI SPKPFTAITV TTDHDAPSLI 540
GMMRKDWASQ NSLALSWQAP AFSNGAILDY EIKYYEKEHE QLTYSSTRSK APSVIVTGLK 600
PATTYIFHIR VRTATGYSGY SQKFEFETGD ETSDMAAEQG QILVIATAAV GGFTLLVILT 660
LFFLITGRCQ WYIKAKMKSE EKRRTHLQNG HLRFPGIKTY IDPDTYEDPS LAVHEFAKEI 720
DPSRIRIERV IGAGEFGEVC SGRLKTPGKR EIPVAIKTLK GGHMDRQRRD FLREASIMGQ 780
FDHPNIIRLE GVVTKRSFPA IGVEAFCPSF LRAGFLNGIQ APHPVTAGGS LPPRIPAGRP 840
VMIVVEYMEN GSLDSFLRKH DGHFTVIQLV GMLRGIASGM KYLSDMGYVH RDLAARNILV 900
NSNLVCKVSD FGLSRVLEDD PEAAYTTTGG KIPIRWTAPE AIAYRKFSSA SDAWSYGIVM 960
WEVMSYGERP YWEMSNQDVI LSIEEGYRLP APMGCPPSLH QLMLHCWQKE RNHRPKFTDI 1020
VSFLDKLIRN PSALHTLVED ILVMPESPGD VPEYPLFVTV GDWLDSIKMG QYKSNFMAAG 1080
FTTFDLISRM SIDDIRRIGV ILIGHQRRIV SSIQTLRLHM MHIQEKGFHV 1130 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005003; F:ephrin receptor activity; IEA:InterPro. 
Interpro
 IPR001090; Ephrin_rcpt_lig-bd_dom.
 IPR003961; Fibronectin_type3.
 IPR008979; Galactose-bd-like.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR013783; Ig-like_fold.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR001426; Tyr_kinase_rcpt_V_CS. 
Pfam
 PF01404; Ephrin_lbd
 PF00041; fn3
 PF07714; Pkinase_Tyr
 PF00536; SAM_1 
SMART
 SM00615; EPH_lbd
 SM00060; FN3
 SM00454; SAM
 SM00219; TyrKc 
PROSITE
 PS51550; EPH_LBD
 PS50853; FN3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00790; RECEPTOR_TYR_KIN_V_1
 PS00791; RECEPTOR_TYR_KIN_V_2
 PS50105; SAM_DOMAIN 
PRINTS
 PR00109; TYRKINASE.