UniProt Accession

 HPCA_RAT; P84076; P32076; P41211; P70510 

Genbank Protein ID

 D12573; AY442172; BC087632; X96993 

Genbank Nucleotide ID

 BAA02122.1; AAR14053.1; AAH87632.1; CAA65718.1 

Protein Name

 Neuron-specific calcium-binding protein hippocalcin 

Protein Synonyms/Alias

 P23K 

Gene Name

 Hpca 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
163	MDTNNDGKLSLEEFI	acetylation	[1]
174	EEFIRGAKSDPSIVR	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions. 

Sequence Annotation

 DOMAIN 24 59 EF-hand 1.
 DOMAIN 60 95 EF-hand 2.
 DOMAIN 96 131 EF-hand 3.
 DOMAIN 144 179 EF-hand 4.
 LIPID 2 2 N-myristoyl glycine.  

Keyword

 Calcium; Complete proteome; Direct protein sequencing; Lipoprotein; Metal-binding; Myristate; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; TAS:ProtInc.
 GO:0048839; P:inner ear development; IEA:Compara. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001125; Recoverin. 

Pfam

 PF00036; efhand 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS

 PR00450; RECOVERIN.