CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015473
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PERQ amino acid-rich with GYF domain-containing protein 2 
Protein Synonyms/Alias
 GRB10-interacting GYF protein 2; Trinucleotide repeat-containing gene 15 protein 
Gene Name
 GIGYF2 
Gene Synonyms/Alias
 KIAA0642; PERQ2; TNRC15 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
688LQQFQTLKMRISDQNubiquitination[1]
1006QQQQQQQKLSGWGNVubiquitination[1]
1105GFWDDAVKEVGPRNSubiquitination[1, 2, 3]
1124KNNASLSKSVGVSNRubiquitination[1, 3]
1144EEEEKLLKLFQGVNKubiquitination[3]
1206LGDTSEAKEFAKQFLubiquitination[3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors. 
Sequence Annotation
 DOMAIN 533 581 GYF.
 REGION 547 563 Required for GRB10-binding (By
 MOD_RES 25 25 Phosphothreonine (By similarity).
 MOD_RES 26 26 Phosphoserine.
 MOD_RES 30 30 Phosphoserine.
 MOD_RES 139 139 Phosphoserine.
 MOD_RES 160 160 Phosphoserine.
 MOD_RES 189 189 Phosphoserine.
 MOD_RES 236 236 Phosphoserine.
 MOD_RES 382 382 Phosphothreonine.
 MOD_RES 593 593 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Neurodegeneration; Parkinson disease; Parkinsonism; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1299 AA 
Protein Sequence
MAAETQTLNF GPEWLRALSS GGSITSPPLS PALPKYKLAD YRYGREEMLA LFLKDNKIPS 60
DLLDKEFLPI LQEEPLPPLA LVPFTEEEQR NFSMSVNSAA VLRLTGRGGG GTVVGAPRGR 120
SSSRGRGRGR GECGFYQRSF DEVEGVFGRG GGREMHRSQS WEERGDRRFE KPGRKDVGKK 180
NGYYCMYSPV LLLGQPLCQG RPNFEEGGPT SVGRKHEFIR SESENWRIFR EEQNGEDEDG 240
GWRLAGSRRD GERWRPHSPD GPRSAGWREH MERRRRFEFD FRDRDDERGY RRVRSGSGSI 300
DDDRDSLPEW CLEDAEEEMG TFDSSGAFLS LKKVQKEPIP EEQEMDFRPV DEGEECSDSE 360
GSHNEEAKEP DKTNKKEGEK TDRVGVASEE TPQTSSSSAR PGTPSDHQSQ EASQFERKDE 420
PKTEQTEKAE EETRMENSLP AKVPSRGDEM VADVQQPLSQ IPSDTASPLL ILPPPVPNPS 480
PTLRPVETPV VGAPGMGSVS TEPDDEEGLK HLEQQAEKMV AYLQDSALDD ERLASKLQEH 540
RAKGVSIPLM HEAMQKWYYK DPQGEIQGPF NNQEMAEWFQ AGYFTMSLLV KRACDESFQP 600
LGDIMKMWGR VPFSPGPAPP PHMGELDQER LTRQQELTAL YQMQHLQYQQ FLIQQQYAQV 660
LAQQQKAALS SQQQQQLALL LQQFQTLKMR ISDQNIIPSV TRSVSVPDTG SIWELQPTAS 720
QPTVWEGGSV WDLPLDTTTP GPALEQLQQL EKAKAAKLEQ ERREAEMRAK REEEERKRQE 780
ELRRQQEEIL RRQQEEERKR REEEELARRK QEEALRRQRE QEIALRRQRE EEERQQQEEA 840
LRRLEERRRE EEERRKQEEL LRKQEEEAAK WAREEEEAQR RLEENRLRME EEAARLRHEE 900
EERKRKELEV QRQKELMRQR QQQQEALRRL QQQQQQQQLA QMKLPSSSTW GQQSNTTACQ 960
SQATLSLAEI QKLEEERERQ LREEQRRQQR ELMKALQQQQ QQQQQKLSGW GNVSKPSGTT 1020
KSLLEIQQEE ARQMQKQQQQ QQQHQQPNRA RNNTHSNLHT SIGNSVWGSI NTGPPNQWAS 1080
DLVSSIWSNA DTKNSNMGFW DDAVKEVGPR NSTNKNKNNA SLSKSVGVSN RQNKKVEEEE 1140
KLLKLFQGVN KAQDGFTQWC EQMLHALNTA NNLDVPTFVS FLKEVESPYE VHDYIRAYLG 1200
DTSEAKEFAK QFLERRAKQK ANQQRQQQQL PQQQQQQPPQ QPPQQPQQQD SVWGMNHSTL 1260
HSVFQTNQSN NQQSNFEAVQ SGKKKKKQKM VRADPSLLGF SVNASSERLN MGEIETLDDY 1320 
Gene Ontology
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0044267; P:cellular protein metabolic process; IEA:Compara.
 GO:0007631; P:feeding behavior; IEA:Compara.
 GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Compara.
 GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0050881; P:musculoskeletal movement; IEA:Compara.
 GO:0017148; P:negative regulation of translation; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0021522; P:spinal cord motor neuron differentiation; IEA:Compara. 
Interpro
 IPR003169; GYF. 
Pfam
 PF02213; GYF 
SMART
 SM00444; GYF 
PROSITE
 PS50829; GYF 
PRINTS