CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026354
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA ligase 
Protein Synonyms/Alias
  
Gene Name
 Lig3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
617RPLCERRKFLHDNMVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 943 AA 
Protein Sequence
MTLAFKTLFP RNLCALGRKE LCLFSEQHHW PAIRQFSQWS ETNLLCGCCL LQRRKPVLSF 60
QRGHLRPRAT HLISWSGSHV GLCTGPCEMA EQRFCVDYAK RGTAGCKKCK EKIVKGVCRI 120
GKVVPNPFSE SGGDMKEWYH IKCMFEKLER ARATTKKIED LTELEGWEEL EDNEKEQISQ 180
HIADLSSKTA ATPKKKATVQ AKLTTTGQVT SPVKGASFIT STNPRKFSGF SAAKPNNSEQ 240
DPSSPAPKTS LSASKCDPKH KDCLLREFRK LCAMVAENPS YNTKTQIIHD FLQKGSTGDG 300
FRGDVYLTVK LLLPGVIKSV YNLNDKQIVK LFSRIFNCNP DDMARDLEQG DVSETIRVFF 360
EQSKSFPPAA KSLLTIQEVD AFLLHLSKLT KEDEQQQALQ DIASRCTAND LKCIIRLIKH 420
DLKMNSGAKH VLDALDPNAY EAFKASRNLQ DVVERVLHNE QEVEKDPGRR RALSVQASLM 480
TPVQPMLAEA CKSIEYAMKK CPNGMFSEIK YDGERVQVHK KGDHFSYFSR SLKPVLPHKV 540
AHFKDYIPKA FPGGQSMILD SEVLLIDNNT GKPLPFGTLG VHKKAAFQDA NVCLFVFDCI 600
YFNDVSLMDR PLCERRKFLH DNMVEIRNRI MFSEMKQVTK ASDLADMINR VIREGLEGLV 660
LKDVKGTYEP GKRHWLKVKK DYLNEGAMAD TADLVVLGAF YGQGSKGGMM SIFLMGCYDP 720
DSQKWCTVTK CAGGHDDATL ARLQKELDMV KISKDPSKIP SWLKINKIYY PDFIVPDPKK 780
AAVWEITGAE FSRSEAHTAD GISIRFPRCT RIRDDKDWKS ATNLPQLKEL YQLSKDKADF 840
AVVAGDEGSS TTGGSNGENE GTAGSTVPRK GPKGPPSKSS ASAKKTEQKL NDPSSRGGEK 900
LAVKSSPVKV GMKRKAADET PGLTKRRRAS RQRGRRAMRT GRR 943 
Gene Ontology
 GO:0005694; C:chromosome; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0000795; C:synaptonemal complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003910; F:DNA ligase (ATP) activity; IBA:RefGenome.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:Compara.
 GO:0006273; P:lagging strand elongation; IBA:RefGenome.
 GO:0043504; P:mitochondrial DNA repair; IEA:Compara.
 GO:0045910; P:negative regulation of DNA recombination; IEA:Compara.
 GO:0006289; P:nucleotide-excision repair; IBA:RefGenome. 
Interpro
 IPR000977; DNA_ligase_ATP-dep.
 IPR012309; DNA_ligase_ATP-dep_C.
 IPR012310; DNA_ligase_ATP-dep_cent.
 IPR016059; DNA_ligase_ATP-dep_CS.
 IPR012308; DNA_ligase_ATP-dep_N.
 IPR012340; NA-bd_OB-fold.
 IPR001510; Znf_PARP. 
Pfam
 PF04679; DNA_ligase_A_C
 PF01068; DNA_ligase_A_M
 PF04675; DNA_ligase_A_N
 PF00645; zf-PARP 
SMART
  
PROSITE
 PS00697; DNA_LIGASE_A1
 PS00333; DNA_LIGASE_A2
 PS50160; DNA_LIGASE_A3
 PS00347; PARP_ZN_FINGER_1
 PS50064; PARP_ZN_FINGER_2 
PRINTS