CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030632
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein transport protein Sec23A 
Protein Synonyms/Alias
 cDNA FLJ45429 fis, clone BRHIP3039057, highly similar to Protein transport protein Sec23A 
Gene Name
 SEC23A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
105MVVGDELKTPIRSWHubiquitination[1]
116RSWHDIDKDNAKYVKubiquitination[2]
360QKFGEYHKDDPSSFRubiquitination[1, 2, 3]
467ETIAQWRKSGYQDMPubiquitination[1, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 563 AA 
Protein Sequence
MLGLSKVPLT QATRGPQVQQ PPPSNRFLQP VQKIDMNLTD LLGELQRDPW PVPQGKRPLR 60
SSGVALSIAV GLLECTFPNT GARIMMFIGG PATQGPGMVV GDELKTPIRS WHDIDKDNAK 120
YVKKGTKHFE ALANRAATTG HVIDIYACAL DQTGLLEMKC CPNLTGGYMV MGDSFNTSLF 180
KQTFQRVFTK DMHGQFKMGF GGTLEIKTSR EIKISGAIGP CVSLNSKGPC VSENEIGTGG 240
TCQWKICGLS PTTTLAIYFE VVNQHNAPIP QGGRGAIQFV TQYQHSSGQR RIRVTTIARN 300
WADAQTQIQN IAASFDQEAA AILMARLAIY RAETEEGPDV LRWLDRQLIR LCQKFGEYHK 360
DDPSSFRFSE TFSLYPQFMF HLRRSSFLQV FNNSPDESSY YRHHFMRQDL TQSLIMIQPI 420
LYAYSFSGPP EPVLLDSSSI LADRILLMDT FFQILIYHGE TIAQWRKSGY QDMPEYENFR 480
HLLQAPVDDA QEILHSRFPM PRYIDTEHGG SQARFLLSKV NPSQTHNNMY AWGQESGAPI 540
LTDDVSLQVF MDHLKKLAVS SAA 563 
Gene Ontology
 GO:0030127; C:COPII vesicle coat; IEA:InterPro.
 GO:0000139; C:Golgi membrane; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR007123; Gelsolin_dom.
 IPR006900; Sec23/24_helical_dom.
 IPR006896; Sec23/24_trunk_dom.
 IPR012990; Sec23_24_beta_S.
 IPR002035; VWF_A. 
Pfam
 PF00626; Gelsolin
 PF08033; Sec23_BS
 PF04815; Sec23_helical
 PF04811; Sec23_trunk 
SMART
  
PROSITE
  
PRINTS