UniProt Accession

 CAZA2_MOUSE; P47754 

Genbank Protein ID

 U16741; BC082589 

Genbank Nucleotide ID

 AAC00567.1; AAH82589.1 

Protein Name

 F-actin-capping protein subunit alpha-2 

Protein Synonyms/Alias

 CapZ alpha-2 

Gene Name

 Capza2 

Gene Synonyms/Alias

 Cappa2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
86	HGDLGNGKFLDPKNR	ubiquitination	[1]
133	TALRAYVKEHYPNGV	ubiquitination	[1]
268	QLPVTRTKIDWNKIL	ubiquitination	[2]
273	RTKIDWNKILSYKIG	ubiquitination	[1, 2]
278	WNKILSYKIGKEMQN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144] 

Functional Description

 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Actin capping; Actin-binding; Complete proteome; Direct protein sequencing; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IDA:MGI.
 GO:0008290; C:F-actin capping protein complex; IPI:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. 

Interpro

 IPR017865; F-actin_cap_asu_CS.
 IPR002189; WASH_F-actin_cap_alpha. 

Pfam

 PF01267; F-actin_cap_A 

SMART

  

PROSITE

 PS00748; F_ACTIN_CAPPING_A_1
 PS00749; F_ACTIN_CAPPING_A_2 

PRINTS

 PR00191; FACTINCAPA.