CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030640
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinoic acid receptor RXR-alpha 
Protein Synonyms/Alias
 cDNA FLJ16020 fis, clone BRAMY2003287, highly similar to RETINOIC ACID RECEPTOR RXR-ALPHA 
Gene Name
 RXRA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
259VLTELVSKMRDMQMDubiquitination[1]
267MRDMQMDKTELGCLRubiquitination[1]
320EQPGRFAKLLLRLPAubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 365 AA 
Protein Sequence
MNPVSSSEDI KPPLGLNGVL KVPAHPSGNM ASFTKHICAI CGDRSSGKHY GVYSCEGCKG 60
FFKRTVRKDL TYTCRDNKDC LIDKRQRNRC QYCRYQKCLA MGMKREAVQE ERQRGKDRNE 120
NEVESTSSAN EDMPVERILE AELAVEPKTE TYVEANMGLN PSSPNDPVTN ICQAADKQLF 180
TLVEWAKRIP HFSELPLDDQ VILLRAGWNE LLIASFSHRS IAVKDGILLA TGLHVHRNSA 240
HSAGVGAIFD RVLTELVSKM RDMQMDKTEL GCLRAIVLFN PDSKGLSNPA EVEALREKVY 300
ASLEAYCKHK YPEQPGRFAK LLLRLPALRS IGLKCLEHLF FFKLIGDTPI DTFLMEMLEA 360
PHQMT 365 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0004886; F:9-cis retinoic acid receptor activity; IEA:Compara.
 GO:0031490; F:chromatin DNA binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060038; P:cardiac muscle cell proliferation; IEA:Compara.
 GO:0007566; P:embryo implantation; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001893; P:maternal placenta development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Compara.
 GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IEA:Compara.
 GO:0055012; P:ventricular cardiac muscle cell differentiation; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 
Interpro
 IPR021780; Nuc_recep-AF1.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR000003; Retinoid-X_rcpt/HNF4.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF11825; Nuc_recep-AF1
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00545; RETINOIDXR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.