CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042503
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase Chk2 
Protein Synonyms/Alias
  
Gene Name
 CHEK2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
117ITDFGHSKILGETSLubiquitination[1]
170IWTQVSLKDQITSGKubiquitination[1]
198KALDLVKKLLVVDPKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 276 AA 
Protein Sequence
XIGSAREADP ALNVETEIEI LKKLNHPCII KIKNFFDAED YYIVLELMEG GELFDKVVGN 60
KRLKEATCKL YFYQMLLAVQ YLHENGIIHR DLKPENVLLS SQEEDCLIKI TDFGHSKILG 120
ETSLMRTLCG TPTYLAPEVL VSVGTAGYNR AVDCWSLGVI LFIWTQVSLK DQITSGKYNF 180
IPEVWAEVSE KALDLVKKLL VVDPKARFTT EEALRHPWLQ DEDMKRKFQD LLSEENESTA 240
LPQVLAQPST SRKRPREGEA EGAETTKRPA VCAAVL 276 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS