CPLM-011014

Genbank Nucleotide ID

Mitochondrial 2-oxoglutarate/malate carrier protein

Protein Synonyms/Alias

OGCP; Solute carrier family 25 member 11

Homo sapiens (Human)

Position	Peptide	Type	References
15	GAGGIDGKPRTSPKS	acetylation	[1]
15	GAGGIDGKPRTSPKS	ubiquitination	[2, 3]
57	QLSGEGAKTREYKTS	ubiquitination	[4, 5, 6]
62	GAKTREYKTSFHALT	ubiquitination	[4, 6]
73	HALTSILKAEGLRGI	acetylation	[7]
73	HALTSILKAEGLRGI	ubiquitination	[4, 6]
162	ADQRRGYKNVFNALI	ubiquitination	[4, 6]

[1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
[2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[7] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]

Functional Description

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

REPEAT 23 108 Solcar 1.
REPEAT 117 208 Solcar 2.
REPEAT 217 306 Solcar 3.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 73 73 N6-acetyllysine.
MOD_RES 102 102 Phosphotyrosine (By similarity).

Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0015367; F:oxoglutarate:malate antiporter activity; TAS:Reactome.
GO:0006094; P:gluconeogenesis; TAS:Reactome.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.

IPR018108; Mitochondrial_sb/sol_carrier.
IPR023395; Mt_carrier_dom.