UniProt Accession

 CSN7A_HUMAN; Q9UBW8; A8K9A6; Q9NVX3; Q9UJW4 

Genbank Protein ID

 AF210052; AB014764; AB033603; AF193844; AK001318; AK021721; AK022488; AK292621; CH471116; CH471116; CH471116; BC011789 

Genbank Nucleotide ID

 AAF19205.1; BAB87805.1; BAA85390.1; AAF04307.1; BAA91620.1; BAG51042.1; BAB14052.1; BAF85310.1; EAW88745.1; EAW88747.1; EAW88748.1; AAH11789.1 

Protein Name

 COP9 signalosome complex subunit 7a 

Protein Synonyms/Alias

 SGN7a; Signalosome subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a 

Gene Name

 COPS7A 

Gene Synonyms/Alias

 CSN7A; DERP10 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	EQFLLLAKSAKGAAL	ubiquitination	[1, 2]
109	VTLAAKVKCIPYAVL	ubiquitination	[3]
199	VSRANQHKEQQLGLK	ubiquitination	[1, 3]
206	KEQQLGLKQQIESEV	ubiquitination	[1, 2, 4]
217	ESEVANLKKTIKVTT	ubiquitination	[1, 2]
221	ANLKKTIKVTTAAAA	ubiquitination	[1, 2, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. 

Sequence Annotation

 DOMAIN 52 156 PCI.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Signalosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 275 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0008180; C:signalosome; IDA:UniProtKB.
 GO:0010388; P:cullin deneddylation; IDA:UniProtKB. 

Interpro

 IPR000717; PCI_dom. 

Pfam

 PF01399; PCI 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS