UniProt Accession

 HLPDA_HUMAN; Q9Y5L2; A4D0Z5; Q52LY5; Q53HJ7 

Genbank Protein ID

 AF144755; AK222583; CH236947; BC001863; BC093742; BC112183 

Genbank Nucleotide ID

 AAD37585.1; BAD96303.1; EAL24309.1; AAH01863.1; AAH93742.1; AAI12184.1 

Protein Name

 Hypoxia-inducible lipid droplet-associated protein 

Protein Synonyms/Alias

 Hypoxia-inducible gene 2 protein 

Gene Name

 HILPDA 

Gene Synonyms/Alias

 C7orf68; HIG2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	LANTEPTKGLPDHPS	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation. 

Sequence Annotation

 REGION 1 37 Required for targeting to lipid droplets.
 MOD_RES 44 44 Phosphoserine.  

Keyword

 Complete proteome; Lipid droplet; Membrane; Phosphoprotein; Reference proteome; Secreted; Stress response; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 63 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0030141; C:secretory granule; IDA:BHF-UCL.
 GO:0035425; P:autocrine signaling; IDA:BHF-UCL.
 GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL.
 GO:0001819; P:positive regulation of cytokine production; IDA:UniProtKB.
 GO:0010884; P:positive regulation of lipid storage; IDA:UniProtKB.
 GO:0006950; P:response to stress; NAS:UniProtKB. 

Interpro

 IPR026190; Hipoxia_HILPDA. 

Pfam

  

SMART

  

PROSITE

  

PRINTS