UniProt Accession

 NDK3_HUMAN; Q13232; Q9BWH4 

Genbank Protein ID

 U29656; AE006639; BC000250 

Genbank Nucleotide ID

 AAA85097.1; AAK61291.1; AAH00250.1 

Protein Name

 Nucleoside diphosphate kinase 3 

Protein Synonyms/Alias

 NDK 3; NDP kinase 3; DR-nm23; Nucleoside diphosphate kinase C; NDPKC; nm23-H3 

Gene Name

 NME3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	ERTFLAVKPDGVQRR	ubiquitination	[1, 2]
51	RFERKGFKLVALKLV	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis. 

Sequence Annotation

 ACT_SITE 135 135 Pros-phosphohistidine intermediate (By
 BINDING 29 29 ATP (By similarity).
 BINDING 77 77 ATP (By similarity).
 BINDING 105 105 ATP (By similarity).
 BINDING 111 111 ATP (By similarity).
 BINDING 122 122 ATP (By similarity).
 BINDING 132 132 ATP (By similarity).  

Keyword

 3D-structure; Apoptosis; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:EC.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 

Interpro

 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.