CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000200
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisomal targeting signal 1 receptor 
Protein Synonyms/Alias
 PTS1 receptor; PTS1R; PTS1-BP; PXR1P; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1 
Gene Name
 Pex5 
Gene Synonyms/Alias
 Pxr1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
28ATHFTQDKALRQEGLubiquitination[1]
170YLEQSEEKLWLGDQEubiquitination[1]
205TASDFVSKVDDPKLAubiquitination[1]
210VSKVDDPKLANSEFLubiquitination[1]
218LANSEFLKFVRQIGEubiquitination[1]
280QVEFERAKSAIESDVubiquitination[1]
302AELEEMAKRDAEAHPubiquitination[1]
456ATGAGPSKRILGSLLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. 
Sequence Annotation
 REPEAT 337 370 TPR 1.
 REPEAT 371 404 TPR 2.
 REPEAT 405 438 TPR 3.
 REPEAT 452 485 TPR 4.
 REPEAT 488 521 TPR 5.
 REPEAT 522 555 TPR 6.
 REPEAT 556 589 TPR 7.
 CROSSLNK 11 11 Glycyl cysteine thioester (Cys-Gly)  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Membrane; Peroxisome; Protein transport; Reference proteome; Repeat; Thioester bond; TPR repeat; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 639 AA 
Protein Sequence
MAMRELVEGE CGGANPLMKL ATHFTQDKAL RQEGLRPGPW PPGASAAETV SKPLGVGTED 60
ELVSEFLQDQ NATLVSRAPQ TFKMDDLLAE MQEIEQSNFR QAPQRAPGVA DLALSENWAQ 120
EFLAAGDAVD VAQDYNETDW SQEFIAEVTD PLSVSPARWA EEYLEQSEEK LWLGDQEGSS 180
TADRWYDEYH PEEDLQHTAS DFVSKVDDPK LANSEFLKFV RQIGEGQVSL ESAAGSGGAQ 240
AEQWAAEFIQ QQGTSEAWVD QFTRPGNKIA ALQVEFERAK SAIESDVDFW DKLQAELEEM 300
AKRDAEAHPW LSDYDDLTSA SYDKGYQFEE ENPLRDHPQP FEEGLHRLEE GDLPNAVLLF 360
EAAVQQDPKH MEAWQYLGTT QAENEQELLA ISALRRCLEL KPDNRTALMA LAVSFTNESL 420
QRQACETLRD WLRYSPAYAH LVAPGEEGAT GAGPSKRILG SLLSDSLFLE VKDLFLAAVR 480
LDPTSIDPDV QCGLGVLFNL SGEYDKAVDC FTAALSVRPN DYLMWNKLGA TLANGNQSEE 540
AVAAYRRALE LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS 600
ENIWSTLRLA LSMLGQSDAY GAADARDLSA LLAMFGLPQ 639 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005782; C:peroxisomal matrix; IEA:Compara.
 GO:0005778; C:peroxisomal membrane; IBA:RefGenome.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005052; F:peroxisome matrix targeting signal-1 binding; IBA:RefGenome.
 GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
 GO:0048468; P:cell development; IMP:MGI.
 GO:0021795; P:cerebral cortex cell migration; IMP:MGI.
 GO:0021895; P:cerebral cortex neuron differentiation; IMP:MGI.
 GO:0007029; P:endoplasmic reticulum organization; IMP:MGI.
 GO:0006635; P:fatty acid beta-oxidation; IMP:MGI.
 GO:0007006; P:mitochondrial membrane organization; IMP:MGI.
 GO:1901094; P:negative regulation of protein homotetramerization; IEA:Compara.
 GO:0050905; P:neuromuscular process; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
 GO:0016560; P:protein import into peroxisome matrix, docking; IBA:RefGenome.
 GO:0016561; P:protein import into peroxisome matrix, translocation; IEA:Compara.
 GO:0045046; P:protein import into peroxisome membrane; IEA:Compara.
 GO:0006625; P:protein targeting to peroxisome; ISS:UniProtKB.
 GO:0051262; P:protein tetramerization; IEA:Compara.
 GO:0000038; P:very long-chain fatty acid metabolic process; IMP:MGI. 
Interpro
 IPR024111; PTS1R_family.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS