UniProt Accession

 CLN8_MOUSE; Q9QUK3 

Genbank Protein ID

 AF125308; AF125307; BC021625 

Genbank Nucleotide ID

 AAF04462.1; AAF04461.1; AAH21625.1 

Protein Name

 Protein CLN8 

Protein Synonyms/Alias

  

Gene Name

 Cln8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
253	NPYWTHKKTQQLLHP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Could play a role in cell proliferation during neuronal differentiation and in protection against cell death (By similarity). 

Sequence Annotation

 DOMAIN 62 262 TLC.
 MOTIF 285 288 ER-retrieval signal.  

Keyword

 Complete proteome; Endoplasmic reticulum; Membrane; Neurodegeneration; Neuronal ceroid lipofuscinosis; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0001306; P:age-dependent response to oxidative stress; IMP:MGI.
 GO:0008306; P:associative learning; IMP:MGI.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0044257; P:cellular protein catabolic process; IMP:MGI.
 GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
 GO:0008203; P:cholesterol metabolic process; ISS:UniProtKB.
 GO:0051935; P:L-glutamate uptake involved in synaptic transmission; IMP:MGI.
 GO:0007040; P:lysosome organization; IMP:MGI.
 GO:0007006; P:mitochondrial membrane organization; IMP:MGI.
 GO:0050881; P:musculoskeletal movement; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0051348; P:negative regulation of transferase activity; IMP:MGI.
 GO:0060052; P:neurofilament cytoskeleton organization; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0050884; P:neuromuscular process controlling posture; IMP:MGI.
 GO:0006644; P:phospholipid metabolic process; ISS:UniProtKB.
 GO:0045494; P:photoreceptor cell maintenance; IMP:MGI.
 GO:0008361; P:regulation of cell size; IMP:MGI.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:0035176; P:social behavior; IMP:MGI.
 GO:0021523; P:somatic motor neuron differentiation; IMP:MGI. 

Interpro

 IPR006634; TLC-dom. 

Pfam

 PF03798; TRAM_LAG1_CLN8 

SMART

 SM00724; TLC 

PROSITE

 PS50922; TLC 

PRINTS