| Tag | Content |
|---|
| CPLM ID | CPLM-015973 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tectonin beta-propeller repeat-containing protein 1 |
Protein Synonyms/Alias | |
Gene Name | TECPR1 |
Gene Synonyms/Alias | KIAA1358 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 86 | PMGGFCEKLLLSDRW | ubiquitination | [1] | | 370 | TPSELSGKTWKAIIA | ubiquitination | [1] | | 373 | ELSGKTWKAIIAARE | ubiquitination | [1] | | 908 | YHGSKTMKDFVRRRC | ubiquitination | [1] | | 1039 | SPPRQRLKQVSAGQT | ubiquitination | [1] | | 1121 | GVQPHEPKGHGWDYG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. |
Sequence Annotation | REPEAT 209 240 TECPR 1.
REPEAT 254 285 TECPR 2.
REPEAT 301 332 TECPR 3.
REPEAT 344 376 TECPR 4.
DOMAIN 611 717 PH.
REPEAT 729 756 TECPR 5.
REPEAT 953 984 TECPR 6.
REPEAT 998 1029 TECPR 7.
REPEAT 1044 1075 TECPR 8.
REPEAT 1087 1127 TECPR 9.
MOD_RES 938 938 Phosphoserine.
MOD_RES 949 949 Phosphoserine. |
Keyword | Alternative splicing; Autophagy; Complete proteome; Cytoplasmic vesicle; Lipid-binding; Lysosome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1165 AA |
Protein Sequence | MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC DNQVYVYVCA 60
SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG LQHRPLDRVA LPSPHWEWES 120
DWYVDENFGG EPTEKGGWTY AIDFPATYTK DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS 180
KDDPKELPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD 240
TPGEVVQISC GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV 300
SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG CEDRAVYFRQ 360
GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV 420
ERPGPGQILP AEPLDDSKNA TGNSASGLGA GRTAEDTVED ACPAEGSREA RPNTHPGPAP 480
TPAELPWTNI DLKEAKKVPS HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG 540
GCVVEACAMP RWFTVQAAGL SSSVHMLSLS ITPAQTAAWR KQIFQQLTER TKRELENFRH 600
YEQAVEQSVW VKTGALQWWC DWKPHKWVDV RLALEQFTGH DGVRDSILFI YYVVHEEKKY 660
IHIFLNEVVA LVPVLNETKH SFALYTPERT RQRWPVRLAA ATEQDMNDWL ALLSLSCCES 720
RKVQGRPSPQ AIWSITCKGD IFVSEPSPDL EAHEHPLPCD QMFWRQMGGH LRMVEANSRG 780
VVWGIGYDHT AWVYTGGYGG GCFQGLASST SNIYTQSDVK CVHIYENQRW NPVTGYTSSR 840
GLPTDRYMWS DASGLQECTK AGTKPPSLQW AWVSDWFVDF SVPGGTDQEG WQYASDFPAS 900
YHGSKTMKDF VRRRCWARKC KLVTSGPWLE VPPIALRDVS IIPESPGAEG SGHSIALWAV 960
SDKGDVLCRL GVSELNPAGS SWLHVGTDQP FASISIGACY QVWAVARDGS AFYRGSVYPS 1020
QPAGDCWYHI PSPPRQRLKQ VSAGQTSVYA LDENGNLWYR QGITPSYPQG SSWEHVSNNV 1080
CRVSVGPLDQ VWVIANKVQG SHSLSRGTVC HRTGVQPHEP KGHGWDYGIG GGWDHISVRA 1140
NATRAPRSSS QEQEPSAPPE AHGPVCC 1167 |
Gene Ontology | GO:0000421; C:autophagic vacuole membrane; IDA:UniProtKB. GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:InterPro. GO:0005765; C:lysosomal membrane; IDA:UniProtKB. GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:UniProtKB. GO:0000046; P:autophagic vacuole fusion; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |