UniProt Accession

 PSME3_MOUSE; P61290; O35563; P97373; Q12920; Q13172; Q9BQD9 

Genbank Protein ID

 D87911; U60330; AB007139; BC015255 

Genbank Nucleotide ID

 BAA22041.1; AAC53297.1; BAA28838.1; AAH15255.1 

Protein Name

 Proteasome activator complex subunit 3 

Protein Synonyms/Alias

 11S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gamma 

Gene Name

 Psme3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
14	VDQEVKLKVDSFRER	ubiquitination	[1]
36	LVANFFPKKLLELDS	ubiquitination	[1]
37	VANFFPKKLLELDSF	ubiquitination	[1]
86	LDGPTYKKRRLDECE	ubiquitination	[1]
121	QLVDIIEKVKPEIRL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 24 24 Phosphoserine (By similarity).
 MOD_RES 205 205 Phosphothreonine.
 MOD_RES 207 207 Phosphothreonine.  

Keyword

 Acetylation; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 254 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008537; C:proteasome activator complex; IEA:InterPro.
 GO:0061133; F:endopeptidase activator activity; IEA:Compara.
 GO:0097371; F:MDM2/MDM4 family protein binding; ISS:UniProtKB.
 GO:0002039; F:p53 binding; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
 GO:0061136; P:regulation of proteasomal protein catabolic process; IEA:Compara. 

Interpro

 IPR003185; Proteasome_activ_REG_asu.
 IPR009077; Proteasome_activ_REG_asu/bsu.
 IPR003186; Proteasome_activ_REG_bsu. 

Pfam

 PF02251; PA28_alpha
 PF02252; PA28_beta 

SMART

  

PROSITE

  

PRINTS