UniProt Accession

 MBTD1_HUMAN; Q05BQ5; Q6ZVU7; Q9NXU1 

Genbank Protein ID

 AK000062; AK124061; AC005839; AC006141; CH471109; BC034364; BC101736 

Genbank Nucleotide ID

 BAA90919.1; BAC85763.1; EAW94562.1; AAH34364.1; AAI01737.1 

Protein Name

 MBT domain-containing protein 1 

Protein Synonyms/Alias

  

Gene Name

 MBTD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	VRDAFYSKTKRFCSV	acetylation	[1, 2]
115	QKQPLVAKLAAYAQY	acetylation	[2]
465	GYTKLPFKWFDYLRE	ubiquitination	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. 

Sequence Annotation

 REPEAT 141 245 MBT 1.
 REPEAT 253 350 MBT 2.
 REPEAT 351 456 MBT 3.
 REPEAT 464 560 MBT 4.
 ZN_FING 45 80 FCS-type.  

Keyword

 3D-structure; Alternative splicing; Chromatin regulator; Complete proteome; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 628 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004092; Mbt.
 IPR012313; Znf_FCS. 

Pfam

 PF02820; MBT 

SMART

 SM00561; MBT 

PROSITE

 PS51079; MBT
 PS51024; ZF_FCS 

PRINTS