CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020334
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 26 member 6 
Protein Synonyms/Alias
 Pendrin-like protein 1; Pendrin-L1 
Gene Name
 SLC26A6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
535VAEYSEAKEVRGVKVubiquitination[1]
629SNNVEDCKMMQVSSGubiquitination[2]
638MQVSSGDKMEDATANubiquitination[1, 3]
651ANGQEDSKAPDGSTLubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Does not seem to be involved in anion transport. 
Sequence Annotation
 DOMAIN 530 742 STAS.
 MOD_RES 616 616 Phosphoserine.
 MOD_RES 752 752 Phosphoserine.
 MOD_RES 755 755 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 759 AA 
Protein Sequence
MGLADASGPR DTQALLSATQ AMDLRRRDYH MERPLLNQEH LEELGRWGSA PRTHQWRTWL 60
QCSRARAYAL LLQHLPVLVW LPRYPVRDWL LGDLLSGLSV AIMQLPQGLA YALLAGLPPV 120
FGLYSSFYPV FIYFLFGTSR HISVGTFAVM SVMVGSVTES LAPQALNDSM INETARDAAR 180
VQVASTLSVL VGLFQVGLGL IHFGFVVTYL SEPLVRGYTT AAAVQVFVSQ LKYVFGLHLS 240
SHSGPLSLIY TVLEVCWKLP QSKVGTVVTA AVAGVVLVVV KLLNDKLQQQ LPMPIPGELL 300
TLIGATGISY GMGLKHRFEV DVVGNIPAGL VPPVAPNTQL FSKLVGSAFT IAVVGFAIAI 360
SLGKIFALRH GYRVDSNQEL VALGLSNLIG GIFQCFPVSC SMSRSLVQES TGGNSQVAGA 420
ISSLFILLII VKLGELFHDL PKAVLAAIII VNLKGMLRQL SDMRSLWKAN RADLLIWLVT 480
FTATILLNLD LGLVVAVIFS LLLVVVRTQM PHYSVLGQVP DTDIYRDVAE YSEAKEVRGV 540
KVFRSSATVY FANAEFYSDA LKQRCGVDVD FLISQKKKLL KKQEQLKLKQ LQKEEKLRKQ 600
AASPKGASVS INVNTSLEDM RSNNVEDCKM MQVSSGDKME DATANGQEDS KAPDGSTLKA 660
LGLPQPDFHS LILDLGALSF VDTVCLKSLK NIFHDFREIE VEVYMAACHS PVVSQLEAGH 720
FFDASITKKH LFASVHDAVT FALQHPRPVP DSPVSVTRL 759 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0031526; C:brush border membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0015301; F:anion:anion antiporter activity; IMP:UniProtKB.
 GO:0015106; F:bicarbonate transmembrane transporter activity; ISS:UniProtKB.
 GO:0015108; F:chloride transmembrane transporter activity; IMP:UniProtKB.
 GO:0015660; F:formate efflux transmembrane transporter activity; ISS:UniProtKB.
 GO:0019531; F:oxalate transmembrane transporter activity; IMP:UniProtKB.
 GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
 GO:0015116; F:sulfate transmembrane transporter activity; IMP:UniProtKB.
 GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.
 GO:0051453; P:regulation of intracellular pH; IMP:UniProtKB.
 GO:0008272; P:sulfate transport; IEA:InterPro.
 GO:0030321; P:transepithelial chloride transport; IMP:UniProtKB. 
Interpro
 IPR018045; S04_transporter_CS.
 IPR002645; STAS_dom.
 IPR001902; SulP_transpt.
 IPR011547; Sulph_transpt. 
Pfam
 PF01740; STAS
 PF00916; Sulfate_transp 
SMART
  
PROSITE
 PS01130; SLC26A
 PS50801; STAS 
PRINTS