UniProt Accession

 TYOBP_MOUSE; O54885; O88603 

Genbank Protein ID

 AF024637; AF077829; BC056450 

Genbank Nucleotide ID

 AAD09438.1; AAC95529.1; AAH56450.1 

Protein Name

 TYRO protein tyrosine kinase-binding protein 

Protein Synonyms/Alias

 DNAX-activation protein 12; Killer-activating receptor-associated protein; KAR-associated protein 

Gene Name

 Tyrobp 

Gene Synonyms/Alias

 Dap12; Karap 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
82	GTAEGTRKQHIAETE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. 

Sequence Annotation

 DOMAIN 81 109 ITAM.
 MOD_RES 92 92 Phosphotyrosine.
 MOD_RES 103 103 Phosphotyrosine.
 DISULFID 37 37 Interchain (By similarity).  

Keyword

 Complete proteome; Disulfide bond; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 114 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0007229; P:integrin-mediated signaling pathway; IMP:UniProtKB.
 GO:0002281; P:macrophage activation involved in immune response; IMP:UniProtKB.
 GO:0002283; P:neutrophil activation involved in immune response; IMP:UniProtKB.
 GO:2001204; P:regulation of osteoclast development; IGI:MGI. 

Interpro

 IPR026200; Tyrobp. 

Pfam

  

SMART

  

PROSITE

 PS51055; ITAM_1 

PRINTS