UniProt Accession

 G45IP_MOUSE; Q9CR59; Q8BT05 

Genbank Protein ID

 AK002738; AK003314; AK028227; AK009723; AK019570; BC061069 

Genbank Nucleotide ID

 BAB22318.1; BAB22710.1; BAC25826.1; BAB26464.1; BAB31797.1; AAH61069.1 

Protein Name

 Growth arrest and DNA damage-inducible proteins-interacting protein 1 

Protein Synonyms/Alias

  

Gene Name

 Gadd45gip1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
59	LTPRYVAKQFGRHGA	ubiquitination	[1]
150	WEKIQADKERRARLQ	acetylation	[2]
184	ELLQDLDKQQRKRLK	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity (By similarity). 

Sequence Annotation

 MOTIF 184 200 Nuclear localization signal (Potential).  

Keyword

 Cell cycle; Coiled coil; Complete proteome; Mitochondrion; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW. 

Interpro

 IPR018472; Damage-induce-interacting_prot. 

Pfam

 PF10147; CR6_interact 

SMART

  

PROSITE

  

PRINTS