CPLM-000235

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-000235

UniProt Accession

ASTN1_HUMAN; O14525; A5PL12; B4DHI9; E9PFR8; O60799; Q5W0V7; Q5W0V8

Genbank Protein ID

AB006627; AK295126; AL136983; AL021398; AL022145; AL031290; AL136983; AL021398; AL022145; AL031290; AL021398; AL022145; AL136983; AL031290; AL021398; AL022145; AL136983; AL031290; AL022145; AL136983; AL031290; AL021398; AL022145; AL136983; AL031290; AL021398; AL031290; AL022145; AL136983; AL021398; AL031290; AL022145; AL136983; AL021398; CH471067; BC142697

Genbank Nucleotide ID

BAA22958.1; BAG58151.1; CAH71678.1; CAH71678.1; CAH71678.1; CAH71678.1; CAH71679.1; CAH71679.1; CAH71679.1; CAH71679.1; CAI23463.1; CAI23463.1; CAI23463.1; CAI23463.1; CAI23464.1; CAI23464.1; CAI23464.1; CAI23464.1; CAI20555.1; CAI20555.1; CAI20555.1; CAI20555.1; CAI20556.1; CAI20556.1; CAI20556.1; CAI20556.1; CAI22718.1; CAI22718.1; CAI22718.1; CAI22718.1; CAI22719.1; CAI22719.1; CAI22719.1; CAI22719.1; EAW91007.1; AAI42698.1

Protein Name

Astrotactin-1

Protein Synonyms/Alias

Gene Name

ASTN1

Gene Synonyms/Alias

ASTN; KIAA0289

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
191	RRVPQPQKSASAEAA	ubiquitination	[1]
281	SLQGCNEKSGMDLTP	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Neuronal adhesion molecule that is required for glial- guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb.

Sequence Annotation

DOMAIN 459 507 EGF-like 1.
DOMAIN 608 652 EGF-like 2.
DOMAIN 656 708 EGF-like 3.
DOMAIN 1030 1145 Fibronectin type-III 1.
MOD_RES 54 54 Phosphoserine (By similarity).
MOD_RES 1088 1088 Phosphoserine (By similarity).
CARBOHYD 115 115 N-linked (GlcNAc...) (Potential).
CARBOHYD 226 226 N-linked (GlcNAc...) (Potential).
CARBOHYD 382 382 N-linked (GlcNAc...) (Potential).
CARBOHYD 453 453 N-linked (GlcNAc...) (Potential).
CARBOHYD 729 729 N-linked (GlcNAc...) (Potential).
CARBOHYD 742 742 N-linked (GlcNAc...) (Potential).
CARBOHYD 804 804 N-linked (GlcNAc...) (Potential).
CARBOHYD 984 984 N-linked (GlcNAc...) (Potential).
DISULFID 463 475 By similarity.
DISULFID 471 490 By similarity.
DISULFID 492 506 By similarity.
DISULFID 612 625 By similarity.
DISULFID 619 636 By similarity.
DISULFID 638 651 By similarity.
DISULFID 660 672 By similarity.
DISULFID 668 692 By similarity.
DISULFID 694 707 By similarity.

Keyword

Alternative splicing; Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1302 AA

Protein Sequence

MALAGLCALL ACCWGPAAVL ATAAGDVDPS KELECKLKSI TVSALPFLRE NDLSIMHSPS 60
ASEPKLLFSV RNDFPGEMVV VDDLENTELP YFVLEISGNT EDIPLVRWRQ QWLENGTLLF 120
HIHHQDGAPS LPGQDPTEEP QHESAEEELR ILHISVMGGM IALLLSILCL VMILYTRRRW 180
CKRRRVPQPQ KSASAEAANE IHYIPSVLIG GHGRESLRNA RVQGHNSSGT LSIRETPILD 240
GYEYDITDLR HHLQRECMNG GEDFASQVTR TLDSLQGCNE KSGMDLTPGS DNAKLSLMNK 300
YKDNIIATSP VDSNHQQATL LSHTSSSQRK RINNKARAGS AFLNPEGDSG TEAENDPQLT 360
FYTDPSRSRR RSRVGSPRSP VNKTTLTLIS ITSCVIGLVC SSHVNCPLVV KITLHVPEHL 420
IADGSRFILL EGSQLDASDW LNPAQVVLFS QQNSSGPWAM DLCARRLLDP CEHQCDPETG 480
RREHRAAGEC LCYEGYMKDP VHKHLCIRNE WGTNQGPWPY TIFQRGFDLV LGEQPSDKIF 540
RFTYTLGEGM WLPLSKSFVI PPAELAINPS AKCKTDMTVM EDAVEVREEL MTSSSFDSLE 600
VLLDSFGPVR DCSKDNGGCS KNFRCISDRK LDSTGCVCPS GLSPMKDSSG CYDRHIGVDC 660
SDGFNGGCEQ LCLQQMAPFP DDPTLYNILM FCGCIEDYKL GVDGRSCQLI TETCPEGSDC 720
GESRELPMNQ TLFGEMFFGY NNHSKEVAAG QVLKGTFRQN NFARGLDQQL PDGLVVATVP 780
LENQCLEEIS EPTPDPDFLT GMVNFSEVSG YPVLQHWKVR SVMYHIKLNQ VAISQALSNA 840
LHSLDGATSR ADFVALLDQF GNHYIQEAIY GFEESCSIWY PNKQVQRRLW LEYEDISKGN 900
SPSDESEERE RDPKVLTFPE YITSLSDSGT KHMAAGVRME CHSKGRCPSS CPLCHVTSSP 960
DTPAEPVLLE VTKAAPIYEL VTNNQTQRLL QEATMSSLWC SGTGDVIEDW CRCDSTAFGA 1020
DGLPTCAPLP QPVLRLSTVH EPSSTLVVLE WEHSEPPIGV QIVDYLLRQE KVTDRMDHSK 1080
VETETVLSFV DDIISGAKSP CAMPSQVPDK QLTTISLIIR CLEPDTIYMF TLWGVDNTGR 1140
RSRPSDVIVK TPCPVVDDVK AQEIADKIYN LFNGYTSGKE QQTAYNTLLD LGSPTLHRVL 1200
YHYNQHYESF GEFTWRCEDE LGPRKAGLIL SQLGDLSSWC NGLLQEPKIS LRRSSLKYLG 1260
CRYSEIKPYG LDWAELSRDL RKTCEEQTLS IPYNDYGDSK EI 1302

Gene Ontology

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016477; P:cell migration; NAS:UniProtKB.
GO:0007626; P:locomotory behavior; IEA:Compara.
GO:0007158; P:neuron cell-cell adhesion; NAS:UniProtKB.

Interpro

IPR026995; Astrotactin.
IPR026996; Astrotactin_1.
IPR000742; EG-like_dom.
IPR003961; Fibronectin_type3.
IPR013783; Ig-like_fold.
IPR020864; MACPF.

Pfam

SMART

SM00181; EGF
SM00060; FN3
SM00457; MACPF

PROSITE

PS00022; EGF_1
PS01186; EGF_2
PS50026; EGF_3
PS50853; FN3

PRINTS