| Tag | Content |
|---|
| CPLM ID | CPLM-004958 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Multidrug resistance protein 3 |
Protein Synonyms/Alias | ATP-binding cassette sub-family B member 4; P-glycoprotein 3 |
Gene Name | ABCB4 |
Gene Synonyms/Alias | MDR3; PGY3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 679 | KNSQMCQKSLDVETD | acetylation | [1] | | 699 | VPPVSFLKVLKLNKT | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. |
Sequence Annotation | DOMAIN 57 359 ABC transmembrane type-1 1.
DOMAIN 394 630 ABC transporter 1.
DOMAIN 711 999 ABC transmembrane type-1 2.
DOMAIN 1034 1279 ABC transporter 2.
NP_BIND 429 436 ATP 1 (By similarity).
NP_BIND 1069 1076 ATP 2 (By similarity).
REGION 625 647 Interaction with HAX1 (By similarity).
CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
CARBOHYD 97 97 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Disease mutation; Glycoprotein; Hydrolase; Intrahepatic cholestasis; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1286 AA |
Protein Sequence | MDLEAAKNGT AWRPTSAEGD FELGISSKQK RKKTKTVKMI GVLTLFRYSD WQDKLFMSLG 60
TIMAIAHGSG LPLMMIVFGE MTDKFVDTAG NFSFPVNFSL SLLNPGKILE EEMTRYAYYY 120
SGLGAGVLVA AYIQVSFWTL AAGRQIRKIR QKFFHAILRQ EIGWFDINDT TELNTRLTDD 180
ISKISEGIGD KVGMFFQAVA TFFAGFIVGF IRGWKLTLVI MAISPILGLS AAVWAKILSA 240
FSDKELAAYA KAGAVAEEAL GAIRTVIAFG GQNKELERYQ KHLENAKEIG IKKAISANIS 300
MGIAFLLIYA SYALAFWYGS TLVISKEYTI GNAMTVFFSI LIGAFSVGQA APCIDAFANA 360
RGAAYVIFDI IDNNPKIDSF SERGHKPDSI KGNLEFNDVH FSYPSRANVK ILKGLNLKVQ 420
SGQTVALVGS SGCGKSTTVQ LIQRLYDPDE GTINIDGQDI RNFNVNYLRE IIGVVSQEPV 480
LFSTTIAENI CYGRGNVTMD EIKKAVKEAN AYEFIMKLPQ KFDTLVGERG AQLSGGQKQR 540
IAIARALVRN PKILLLDEAT SALDTESEAE VQAALDKARE GRTTIVIAHR LSTVRNADVI 600
AGFEDGVIVE QGSHSELMKK EGVYFKLVNM QTSGSQIQSE EFELNDEKAA TRMAPNGWKS 660
RLFRHSTQKN LKNSQMCQKS LDVETDGLEA NVPPVSFLKV LKLNKTEWPY FVVGTVCAIA 720
NGGLQPAFSV IFSEIIAIFG PGDDAVKQQK CNIFSLIFLF LGIISFFTFF LQGFTFGKAG 780
EILTRRLRSM AFKAMLRQDM SWFDDHKNST GALSTRLATD AAQVQGATGT RLALIAQNIA 840
NLGTGIIISF IYGWQLTLLL LAVVPIIAVS GIVEMKLLAG NAKRDKKELE AAGKIATEAI 900
ENIRTVVSLT QERKFESMYV EKLYGPYRNS VQKAHIYGIT FSISQAFMYF SYAGCFRFGA 960
YLIVNGHMRF RDVILVFSAI VFGAVALGHA SSFAPDYAKA KLSAAHLFML FERQPLIDSY 1020
SEEGLKPDKF EGNITFNEVV FNYPTRANVP VLQGLSLEVK KGQTLALVGS SGCGKSTVVQ 1080
LLERFYDPLA GTVFVDFGFQ LLDGQEAKKL NVQWLRAQLG IVSQEPILFD CSIAENIAYG 1140
DNSRVVSQDE IVSAAKAANI HPFIETLPHK YETRVGDKGT QLSGGQKQRI AIARALIRQP 1200
QILLLDEATS ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV VFQNGRVKEH 1260
GTHQQLLAQK GIYFSMVSVQ AGTQNL 1286 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IBA:RefGenome. GO:0000139; C:Golgi membrane; IBA:RefGenome. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0046581; C:intercellular canaliculus; IBA:RefGenome. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:RefGenome. GO:0008559; F:xenobiotic-transporting ATPase activity; IEA:EC. GO:0044255; P:cellular lipid metabolic process; TAS:Reactome. GO:0042493; P:response to drug; TAS:ProtInc. |
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