UniProt Accession

 GSTA1_RAT; P00502; Q6AZ72 

Genbank Protein ID

 K01931; BC078706 

Genbank Nucleotide ID

 AAA41283.1; AAH78706.1 

Protein Name

 Glutathione S-transferase alpha-1 

Protein Synonyms/Alias

 GST 1-1; GST 1a-1a; GST A1-1; GST B; Glutathione S-transferase Ya-1; GST Ya1; Ligandin; Glutathione S-transferase alpha-1, N-terminally processed 

Gene Name

 Gsta1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MSGKPVLHYFN	acetylation	[1]
211	RKLPVDAKQIEEARK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 3 83 GST N-terminal.
 DOMAIN 85 208 GST C-terminal.
 REGION 67 68 Glutathione binding.
 BINDING 9 9 Glutathione.
 BINDING 45 45 Glutathione.
 BINDING 55 55 Glutathione; via amide nitrogen and
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylserine; in Glutathione S-  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005640; C:nuclear outer membrane; IDA:RGD.
 GO:0008144; F:drug binding; IDA:RGD.
 GO:0043295; F:glutathione binding; IDA:RGD.
 GO:0004364; F:glutathione transferase activity; IDA:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0042493; P:response to drug; NAS:RGD.
 GO:0031667; P:response to nutrient levels; IEP:RGD.
 GO:0042178; P:xenobiotic catabolic process; IDA:RGD. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR003080; GST_alpha.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01266; GSTRNSFRASEA.