UniProt Accession

 FTSZ_ECOLI; P0A9A6; P06138; P77857; P78047 

Genbank Protein ID

 U00096; AP009048; X55034; K02668; M19211 

Genbank Nucleotide ID

 AAC73206.1; BAB96663.2; CAA38872.1; AAA23818.1; AAA83848.1 

Protein Name

 Cell division protein FtsZ 

Protein Synonyms/Alias

  

Gene Name

 ftsZ 

Gene Synonyms/Alias

 sfiB; sulB; b0095; JW0093 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
133	LTVAVVTKPFNFEGK	acetylation	[1]
140	KPFNFEGKKRMAFAE	acetylation	[1]
141	PFNFEGKKRMAFAEQ	acetylation	[1]
155	QGITELSKHVDSLIT	acetylation	[1]
167	LITIPNDKLLKVLGR	acetylation	[1]
170	IPNDKLLKVLGRGIS	acetylation	[1]
319	ATGIGMDKRPEITLV	acetylation	[1]
329	EITLVTNKQVQQPVM	acetylation	[1]
352	APLTQEQKPVAKVVN	acetylation	[1]
356	QEQKPVAKVVNDNAP	acetylation	[1, 2]
367	DNAPQTAKEPDYLDI	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. Polymerization and bundle formation is enhanced by CbeA. 

Sequence Annotation

 NP_BIND 103 111 GTP (Potential).  

Keyword

 3D-structure; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Nucleotide-binding; Reference proteome; Septation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 383 AA 

Protein Sequence

Gene Ontology

 GO:0032153; C:cell division site; IEA:HAMAP.
 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0043234; C:protein complex; IEA:InterPro.
 GO:0005525; F:GTP binding; IDA:EcoliWiki.
 GO:0003924; F:GTPase activity; IDA:EcoliWiki.
 GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IMP:EcoliWiki.
 GO:0043093; P:cytokinesis by binary fission; IEA:HAMAP.
 GO:0051258; P:protein polymerization; IDA:EcoliWiki. 

Interpro

 IPR000158; Cell_div_FtsZ.
 IPR020805; Cell_div_FtsZ_CS.
 IPR024757; FtsZ_C.
 IPR008280; Tub_FtsZ_C.
 IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
 IPR003008; Tubulin_FtsZ_GTPase. 

Pfam

 PF12327; FtsZ_C
 PF00091; Tubulin 

SMART

 SM00864; Tubulin
 SM00865; Tubulin_C 

PROSITE

 PS01134; FTSZ_1
 PS01135; FTSZ_2 

PRINTS

 PR00423; CELLDVISFTSZ.