| Tag | Content |
|---|
| CPLM ID | CPLM-024646 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase epsilon |
Protein Synonyms/Alias | Protein-tyrosine phosphatase epsilon; R-PTP-epsilon |
Gene Name | Ptpre |
Gene Synonyms/Alias | Ptpe |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 662 | LDVFQAVKSLRLQRP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. |
Sequence Annotation | DOMAIN 134 393 Tyrosine-protein phosphatase 1.
DOMAIN 425 688 Tyrosine-protein phosphatase 2.
REGION 334 340 Substrate binding (By similarity).
ACT_SITE 334 334 Phosphocysteine intermediate (By
ACT_SITE 629 629 Phosphocysteine intermediate (By
BINDING 302 302 Substrate (By similarity).
BINDING 378 378 Substrate (By similarity).
MOD_RES 695 695 Phosphotyrosine (By similarity).
CARBOHYD 23 23 N-linked (GlcNAc...) (Potential).
CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative initiation; Alternative promoter usage; Cell membrane; Complete proteome; Cytoplasm; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 699 AA |
Protein Sequence | MEPFCPLLLA SFSLSLATAG QGNDTTPTES NWTSTTAGPP DPGTSQPLLT WLLLPLLLLL 60
FLLAAYFFRF RKQRKAVVNS NDKKMPNGIL EEQEQQRVML LSRSPSGPKK YFPIPVEHLE 120
EEIRVRSADD CKRFREEFNS LPSGHIQGTF ELANKEENRE KNRYPNILPN DHCRVILSQL 180
DGIPCSDYIN ASYIDGYKEK NKFIAAQGPK QETVNDFWRM VWEQRSATIV MLTNLKERKE 240
EKCYQYWPDQ GCWTYGNIRV CVEDCVVLVD YTIRKFCIHP QLPDSCKAPR LVSQLHFTSW 300
PDFGVPFTPI GMLKFLKKVK TLNPSHAGPI VVHCSAGVGR TGTFIVIDAM MDMIHSEQKV 360
DVFEFVSRIR NQRPQMVQTD VQYTFIYQAL LEYYLYGDTE LDVSSLERHL QTLHGTATHF 420
DKIGLEEEFR KLTNVRIMKE NMRTGNLPAN MKKARVIQII PYDFNRVILS MKRGQEFTDY 480
INASFIDGYR QKDYFMATQG PLAHTVEDFW RMVWEWKSHT IVMLTEVQER EQDKCYQYWP 540
TEGSVTHGDI TIEIKSDTLS EAISIRDFLV TFKQPLARQE EQVRMVRQFH FHGWPEVGIP 600
TEGKGMIDLI AAVQKQQQQT GNHPITVHCS AGAGRTGTFI ALSNILERVK AEGLLDVFQA 660
VKSLRLQRPH MVQTLEQYEF CYKVVQDFID IFSDYANFK 699 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara. GO:0005634; C:nucleus; IEA:Compara. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004725; F:protein tyrosine phosphatase activity; NAS:RGD. GO:0046627; P:negative regulation of insulin receptor signaling pathway; IDA:UniProtKB. GO:0033003; P:regulation of mast cell activation; IEA:Compara. GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |