CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012986
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fumarylacetoacetate hydrolase domain-containing protein 2A 
Protein Synonyms/Alias
  
Gene Name
 Fahd2 
Gene Synonyms/Alias
 Fahd2a 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
128EQNVRVPKSPIIFSKacetylation[1]
128EQNVRVPKSPIIFSKsuccinylation[1]
174GKKGKHIKATDVMAHacetylation[2]
202DWQMRNGKQWLLGKTacetylation[1, 2, 3, 4]
202DWQMRNGKQWLLGKTsuccinylation[1]
223LGPALVTKDTIADPHacetylation[3]
233IADPHNLKICCRVNGacetylation[2, 3, 4, 5]
293RKPPVFLKKGDEVQCacetylation[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758
Functional Description
 May have hydrolase activity (By similarity). 
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 313 AA 
Protein Sequence
MLGFGRRRLF SALLQVQKRP CQPSRNMRLV QFQAPHLEEP HLGLESGVGG GVVDLNAFDS 60
TLPKTMVQFL EQGETTLSVA RRALATQLPV IPRSQVTFLA PVTRPEKVIC VGLNYADHCQ 120
EQNVRVPKSP IIFSKFSSSI VGPYDEIILP PESKEVDWEV EMAVVIGKKG KHIKATDVMA 180
HVAGFTVAHD VSARDWQMRN GKQWLLGKTF DTFCPLGPAL VTKDTIADPH NLKICCRVNG 240
EVVQSSNTNQ MVFKTEYLIA WVSQFVTLYP GDLLLTGTPP GVGMFRKPPV FLKKGDEVQC 300
EIEELGVIIN KVV 313 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR002529; Fumarylacetoacetase_C.
 IPR011234; Fumarylacetoacetase_C-rel. 
Pfam
 PF01557; FAA_hydrolase 
SMART
  
PROSITE
  
PRINTS