CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043537
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Origin recognition complex subunit 6 
Protein Synonyms/Alias
  
Gene Name
 ORC6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21LDRAYLIKLSGLNKEubiquitination[1]
27IKLSGLNKETYQSCLubiquitination[1]
70NMASKILKSYESSLPubiquitination[1, 2]
128AIFDRLCKQLEKIGQubiquitination[1]
189DYEEWKRKILENAASubiquitination[1]
199ENAASAQKATAE***ubiquitination[1, 3, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 203 AA 
Protein Sequence
MCLDLAASWM KCPLDRAYLI KLSGLNKETY QSCLKSFECL LGLNSNIGIR DLAVQFSCIE 60
AVNMASKILK SYESSLPQTQ QVDLDLSRPL FTSAALLSAC KILKLKVDKN KMVATSGVKK 120
AIFDRLCKQL EKIGQQVDRE PGDVATPPRK RKKIVVEAPA KEMEKVEEMP HKPQKDEDLT 180
QDYEEWKRKI LENAASAQKA TAE 203 
Gene Ontology
 GO:0005664; C:nuclear origin of replication recognition complex; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006261; P:DNA-dependent DNA replication; IEA:Compara. 
Interpro
 IPR008721; ORC6.
 IPR020529; ORC6_met/pln. 
Pfam
 PF05460; ORC6 
SMART
  
PROSITE
  
PRINTS