Tag | Content |
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CPLM ID | CPLM-009517 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongation factor 1-alpha 1 |
Protein Synonyms/Alias | EF-1-alpha-1; Elongation factor Tu; EF-Tu; Eukaryotic elongation factor 1 A-1; eEF1A-1 |
Gene Name | Eef1a1 |
Gene Synonyms/Alias | Eef1a |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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44 | RTIEKFEKEAAEMGK | ubiquitination | [1] | 165 | TEPPYSQKRYEEIVK | ubiquitination | [1] | 439 | TVAVGVIKAVDKKAA | ubiquitination | [1] | 450 | KKAAGAGKVTKSAQK | ubiquitination | [1] |
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Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity). |
Sequence Annotation | NP_BIND 14 21 GTP (By similarity). NP_BIND 91 95 GTP (By similarity). NP_BIND 153 156 GTP (By similarity). MOD_RES 29 29 Phosphotyrosine (By similarity). MOD_RES 36 36 N6,N6,N6-trimethyllysine (By similarity). MOD_RES 55 55 N6,N6,N6-trimethyllysine; alternate (By MOD_RES 55 55 N6,N6-dimethyllysine; alternate (By MOD_RES 79 79 N6,N6,N6-trimethyllysine (By similarity). MOD_RES 141 141 Phosphotyrosine (By similarity). MOD_RES 165 165 N6,N6,N6-trimethyllysine; alternate (By MOD_RES 165 165 N6,N6-dimethyllysine; alternate (By MOD_RES 179 179 N6-acetyllysine (By similarity). MOD_RES 300 300 Phosphoserine; by TGFBR1 (By similarity). MOD_RES 301 301 5-glutamyl glycerylphosphorylethanolamine MOD_RES 318 318 N6,N6,N6-trimethyllysine (By similarity). MOD_RES 374 374 5-glutamyl glycerylphosphorylethanolamine MOD_RES 432 432 Phosphothreonine; by PASK (By MOD_RES 439 439 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Elongation factor; GTP-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 462 AA |
Protein Sequence | MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL 60 DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV 120 GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK 180 IGYNPDTVAF VPISGWNGDN MLEPSANMPW FKGWKVTRKD GSASGTTLLE ALDCILPPTR 240 PTDKPLRLPL QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS 300 EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP GQISAGYAPV 360 LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA IVDMVPGKPM CVESFSDYPP 420 LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK VTKSAQKAQK AK 462 |
Gene Ontology | |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |