UniProt Accession

 PAX5_HUMAN; Q02548; A3QVP6; A3QVP7; A3QVP8; O75933; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732 

Genbank Protein ID

 M96944; AY463952; AY463953; AY463954; AY463955; AY463956; AY463957; EF064717; AL161781; AL450267; AL450267; AL161781; CH471071; CH471071; CH471071; CH471071; CH471071; CH471071; DQ841178; DQ845345; DQ845346; AF080573 

Genbank Nucleotide ID

 AAA58397.1; AAR27590.1; AAR27591.1; AAR27592.1; AAR27593.1; AAR27594.1; AAR27595.1; ABK41900.1; CAH72137.1; CAH72137.1; CAH72740.1; CAH72740.1; EAW58294.1; EAW58295.1; EAW58296.1; EAW58297.1; EAW58298.1; EAW58299.1; ABI30005.1; ABI33104.1; ABI33105.1; AAC35286.1 

Protein Name

 Paired box protein Pax-5 

Protein Synonyms/Alias

 B-cell-specific transcription factor; BSAP 

Gene Name

 PAX5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MDLEKNYPTPRT	acetylation	[1]
67	VSHGCVSKILGRYYE	acetylation	[1]
79	YYETGSIKPGVIGGS	acetylation	[1]
87	PGVIGGSKPKVATPK	acetylation	[1]
89	VIGGSKPKVATPKVV	acetylation	[1]
94	KPKVATPKVVEKIAE	acetylation	[1]
98	ATPKVVEKIAEYKRQ	acetylation	[1]
103	VEKIAEYKRQNPTMF	acetylation	[1]

Reference

 [1] Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity.
 He T, Hong SY, Huang L, Xue W, Yu Z, Kwon H, Kirk M, Ding SJ, Su K, Zhang Z.
 J Biol Chem. 2011 Apr 22;286(16):14137-45. [PMID: 21357426] 

Functional Description

 May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. 

Sequence Annotation

 DOMAIN 16 142 Paired.  

Keyword

 3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; Developmental protein; Differentiation; DNA-binding; Glycoprotein; Neurogenesis; Nucleus; Paired box; Polymorphism; Proto-oncogene; Reference proteome; Spermatogenesis; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 391 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006959; P:humoral immune response; TAS:ProtInc.
 GO:0051573; P:negative regulation of histone H3-K9 methylation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR009057; Homeodomain-like.
 IPR001523; Paired_dom.
 IPR022130; Pax2_C.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00292; PAX
 PF12403; Pax2_C 

SMART

 SM00351; PAX 

PROSITE

 PS00034; PAIRED_1
 PS51057; PAIRED_2 

PRINTS

 PR00027; PAIREDBOX.